URUBANZA ： 152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

LVV-hemorphine-7 (LVV-h7) ni peptide ya bioactive iterwa no kwangirika kwa gemoglobine β-globine.LVV-h7 ni agoniste yihariye ya reseptor ya angiotensin IV.Iyi reseptor iri mubyiciro bya insuline bigengwa na aminopeptidase (IRAP) kandi ifite ibikorwa bya oxytocine.Hano, tugamije gusuzuma: i) niba LVV-h7 ihindura imyitwarire yumubiri wibanze hamwe nigisubizo cyumutima nimiyoboro yumutima kumaganya, na ii) uburyo bwibanze bwingaruka za LVV-h7 burimo gukora reseptor ya oxytocine (OT), ishobora kuba ibisubizo byo kugabanya ibikorwa bya proteolytic ya IRAP mugihe cyamasaha y'ikirenga.Imbeba zikuze z'umugabo Wistar (270 - 370 g) yakiriye (ip) LVV-h7 (153 nmol / kg) cyangwa umutwara (0.1 ml).Porotokole zitandukanye zakoreshejwe: i) Gufungura ikibuga (OP) kugerageza ibikorwa bya siporo / ubushakashatsi;ii) Kuzamura umusaraba wa mazutu (EPMs) kubitekerezo bisa n'amaganya;iii) Ikizamini cyo koga ku gahato (FST) ku myitwarire isa no kwiheba na iv) gutera inshinge zo mu mutima kugira ngo umutima uhindurwe n'umutima ukabije.Diazepam (2 mg / kg) na imipramine (15 mg / kg) byakoreshejwe nk'igenzura ryiza kuri EPM na FST.OT reseptor (OTr) antagonist atosiban (1 na 0.1 mg / kg) yakoreshejwe kugirango hamenyekane uruhare rwinzira ya oxytocine.Twasanze LVV-h7: i) yongereye umubare winjira nigihe cyakoreshejwe mumaguru n'amaboko afunguye, byerekana kurwanya amaganya;ii) Kubyutsa ingaruka zirwanya antidepressant mu bizamini bya FS;iii) Kongera ubushakashatsi no kugenda;iv) ntabwo yahinduye ibisubizo byumutima nimiyoboro na neuroendocrine kubibazo bikabije.Byongeye kandi, imyitozo yiyongereye hamwe na LVV-h7 itera antidepressant yagaruwe na OTr antagonist.Twanzuye ko LVV-h7 ihindura imyitwarire yerekanwe igice na reseptor ya oxytocine.