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ibicuruzwa

Anti-Estrogene ikora neza Exemestane / Ifu ya Aromasine Kubona imitsi CAS 107868-30-4

ibisobanuro bigufi:

Ibisobanuro birambuye ku bicuruzwa

Irindi zina:Aromasin
MF:C20H24O2
MW:296.4
Depite:155.13 ° C.
Ububiko bwububiko:Ubike kuri -20 ° C.
Igikorwa:Kurwanya Estrogene
Kugaragara:Ifu yera ya Crystalline, Impumuro nziza
Umucyo mwinshi:Ibicuruzwa birwanya Estrogene, Ibiyobyabwenge birwanya Estrogene


Ibicuruzwa birambuye

Ibicuruzwa

Exemestane (Aromasin)Ibisobanuro birambuye

Izina ryibicuruzwa: Exemestane
Synonyme: Aromasin
CAS: 107868-30-4
MF: C20H24O2
MW: 296.4
mp: 155.13 ° C.
ububiko bwo kubika: Ubike kuri -20 ° C.
isura: ifu yera kugeza yoroheje umuhondo wa kirisiti

Ibisobanuro:
Aromasin ikoreshwa mu kurwanya kanseri y'ibere no kuzamura testosterone mu mubiri.
Exemestane ihagarika inzira ya aromatisation.Igabanya rero urugero rwa estrogene mu mubiri.Muri kanseri y'ibere kare, gufata exemestane birashobora gufasha guhagarika kanseri y'ibere kugaruka.Muri kanseri y'ibere yateye imbere kanseri irashobora gukura buhoro cyangwa guhagarika gukura burundu.
Exemestane ni inhibitor ya aromatase.Ibi bivuze ko ihagarika enzyme aromatase (iboneka mumitsi yumubiri, uruhu, amabere hamwe namavuta), ikoreshwa muguhindura andorogene (imisemburo ikorwa na glande ya adrenal) muri estrogene.Mugihe estrogene idahari, ibibyimba biterwa niyi misemburo yo gukura bizagabanuka

Exemestane (1)

Ikoreshwa rya Exemestane (Aromasin)

Ikoreshwa mu kuvura kanseri y'ibere metastatike kandi ikoreshwa nk'imfashanyo yo kuvura kanseri y'ibere hakiri kare.

1. Nimwe mubintu bikomeye bya estrogene ikuraho ibintu.
2. Nibimwe mubintu byiza byo kugabanya ingaruka za aromatizing ya steroid.
3. Iraboneka kububaka umubiri bafata anabolike steroid.
4. Ikora muguhagarika enzyme aromatase, nyuma ikabuza umusaruro wa estrogene.
5. Nubwoko bwa antineoplastique (hormone) ibikoresho fatizo.

Exemestane (Aromasin)Porogaramu

Aromasin ikoreshwa mu kurwanya kanseri y'ibere no kuzamura testosterone mu mubiri.
Exemestane acetate ihagarika inzira ya aromatisation.Igabanya rero urugero rwa estrogene mu mubiri.Muri kanseri y'ibere kare, gufata acemate ya exemestane birashobora gufasha guhagarika kanseri y'ibere kugaruka.Muri kanseri y'ibere yateye imbere kanseri irashobora gukura buhoro cyangwa guhagarika gukura burundu.

Inhibitor nyinshi za aromatase ntabwo ari steroid muburyo ubwo aribwo bwose ariko hano tugomba gukora ibintu bidasanzwe.Sobanukirwa, benshi bagura Aromasin barabikora kuko ikoreshwa nizindi steroyide birashobora kuba ingenzi cyane kubyerekeye ingaruka mbi ariko Aromasin ubwayo itwara imico ya andorogene.Nubwo bimeze bityo, mugihe dufite kamere ya androgeneque ni estrogene yayo igabanya cyane cyane duhangayikishijwe.

igisekuru cya gatatu aromatase inhibitor, ikoreshwa mukuvura kanseri y'ibere metastatike kandi ikoreshwa nk'imfashanyo yo kuvura kanseri y'ibere hakiri kare.
Kanseri nyinshi y'ibere ishishikarizwa gukura na hormone igitsina gore estrogene na progesterone.Iyi kanseri y'ibere yitwa hormone sensibilité cyangwa hormone reseptor nziza kandi irashobora kuvurwa n'imiti ibuza ingaruka ziyi misemburo.

Mu bagore bagize gucura, estrogene ikorwa cyane cyane no guhindura andorogene (imisemburo yimibonano mpuzabitsina ikorwa na glande ya adrenal) ihinduka oestrogène.Ubu buryo bwitwa aromatisation kandi bibaho cyane cyane mubice byamavuta, imitsi nuruhu.Irakeneye enzyme yihariye yitwa aromatase.
Aromasin ihagarika inzira ya aromatisation.Igabanya rero urugero rwa estrogene mu mubiri.Muri kanseri y'ibere kare, gufata Aromasin birashobora gufasha guhagarika kanseri y'ibere kugaruka.Muri kanseri y'ibere yateye imbere kanseri irashobora gukura buhoro cyangwa guhagarika gukura burundu.

Exemestane (4)
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2CF15DBA-28DD-4a76-8CFE-0A38764249E5

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