Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Kugwiritsa ntchito mankhwala
Toluene thiazide amagwiritsidwa ntchito ngati sedative, kumasuka kwa minofu ndi analgesic.Nthawi zambiri amagwiritsidwa ntchito pochiza kafumbata.Xylazine ndi ofanana kwambiri ndi mankhwala monga phenothiazine, tricyclic antidepressants ndi clonidine.Monga mankhwala oletsa ululu, nthawi zambiri amagwiritsidwa ntchito limodzi ndi ketamine.Xylazine ikuwoneka kuti imachepetsa chidwi cha thupi ku insulini ndi kutengeka kwa shuga.Yohimbine ndi alpha2 adrenergic receptor antagonist yomwe yagwiritsidwa ntchito kuchepetsa milingo ya shuga kukhala yathanzi.Yohimbine amasintha zotsatira za toluene thiazide m'malo azachipatala ngati ataperekedwa kudzera m'mitsempha patangopita nthawi pang'ono kuperekedwa kwa toluene thiazide.

pharmacodynamics

Xylazine ndi wamphamvu alpha 2 adrenergic agonist.Toluene thiazide ndi ma alpha2 adrenergic receptor agonists amagawidwa mthupi lonse mkati mwa mphindi 30-40 akapatsidwa.Chifukwa cha kuchuluka kwa lipophilicity, toluene thiazide imalimbikitsa mwachindunji α2 zolandilira komanso zotumphukira za αadrenergic zolandilira m'magulu osiyanasiyana.Monga agonist, toluene thiazide imabweretsa kuchepa kwapang'onopang'ono kwa norepinephrine ndi dopamine m'katikati mwa mitsempha ya mitsempha.Zimatero potengera kumangidwa kwa norepinephrine ku autoreceptors pamtunda wa presynaptic, zomwe zimabweretsa kuletsa kwa mayankho a norepinephrine.

Xylazine imagwiranso ntchito ngati inhibitor yoyendetsa galimoto poletsa ntchito yoyendetsa norepinephrine mwa mpikisano woletsa kayendedwe ka gawo lapansi.Chifukwa chake, toluene thiazide idachulukitsa K m ndipo sizinakhudze V max.Izi zitha kuchitika polumikizana mwachindunji ndi zigawo zomwe zimalumikizana ndi malo omangira antidepressant.Mwachitsanzo, toluene thiazide ndi clonidine amalepheretsa kutenga MIBG (analogue ya norepinephrine) ndi maselo a neuroblastoma.Xylazine ili ndi zosiyana zosiyana za cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, ndi opioid receptors.Mapangidwe ake a mankhwala ndi ofanana kwambiri ndi a phenothiazines, tricyclic antidepressants ndi clonidine