Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507

Tesamorelin (INN) (dzina la malonda Egrifta SV) ndi njira yopangira kukula kwa hormone yotulutsa hormone (GHRH) pofuna kuchiza lipodystrophy yokhudzana ndi HIV ndipo inavomerezedwa poyamba mu 2010. Imapangidwa ndikupangidwa ndi Theratechnologies, Inc. Canada.Mankhwalawa ndi peptide yopanga yopangidwa ndi ma amino acid onse 44 a GHRH yamunthu ndikuwonjezera gulu la trans-3-hexenoic acid.

Njira yochitira
Tesamorelin ndi N-terminus yosinthidwa pawiri yochokera ku 44 amino acid sequence of human GHRH.Mawonekedwe opangidwa osinthidwawa ndiwothandiza komanso okhazikika kuposa ma peptide achilengedwe.Imalimbananso kwambiri ndi dipeptide aminopeptidase kuposa GHRH yamunthu.Zimalimbikitsa kaphatikizidwe ka GH ndikumasulidwa ndikuwonjezera kuchuluka kwa insulin-monga kukula factor (IGF-1).GH yotulutsidwa ndiye imamangiriza ku ma receptor omwe amapezeka pazigawo zosiyanasiyana za thupi ndikuwongolera kapangidwe ka thupi.Lamuloli makamaka chifukwa cha kuphatikiza kwa anabolic ndi lipolysis njira.Komabe, njira yayikulu yomwe tesamoline yapezeka kuti ichepetse mafuta amthupi ndikuchepetsa kwa triglyceride pambuyo pa lipolysis.