SARM SR9011 Pharmaceutical Raw Powder for Boosting Exercise Kupirira CAS 1379686-30-2
Zambiri za SR9011
Cas No 1379686-29-9
Mawu ofanana ndi 3-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Chithunzi cha C23H31ClN4O3S
Kulemera kwa Molucelar 479.03524
SR9011Kufotokozera
SR9011 ndi trifunctional methacrylate monoma yomwe imapereka kumamatira kwapadera kuchitsulo.
magawo.
SR9011 ikulimbikitsidwa kuti igwiritsidwe ntchito mu zokutira zochiritsidwa ndi peroxide, zosindikizira, ndi ma plastisols opangidwa ndi PVC.
Kugwiritsa ntchito 5% mpaka 10% kulemera kumalimbikitsidwa.
SR9011 ndi yamphamvu komanso yapadera yopanga REV-ERB.Ilinso ndi zabwino mu vivo plasma / kuwonekera kwaubongo.
Ma nyukiliya receptors REV-ERB-α ndi REV-ERB-β amagwira ntchito yofunika kwambiri pakuwongolera mawu.
Mapuloteni apakati pawotchi, kuyendetsa kayimbidwe muzochita ndi metabolism.Kuwongolera kwa SR9011 zosintha
khalidwe la circadian ndi circadian pattern of core clock gene expression mu hypothalami ya mbewa.
Mawonekedwe a circadian amitundu yambiri yama metabolic m'chiwindi, chigoba ndi minofu.
minyewa ya adipose idasinthidwanso, zomwe zidapangitsa kuti ndalama ziwonjezeke.Kuchiza chifukwa cha zakudya
mbewa onenepa ndi SR9011 adachepetsa kunenepa kwambiri pochepetsa kuchuluka kwamafuta ndikuwongolera bwino dyslipidemia ndi hyperglycemia.Zotsatira izi zikuwonetsa kuti ma ligand a REV-ERB opangidwa omwe amayang'ana pamankhwala
circadian rhythm ingakhale yopindulitsa pochiza matenda ogona komanso matenda a metabolic.
Momwe mungagwiritsire ntchito SR9011?
In vitro: SR9011 idagwiritsidwa ntchito pa 5-10 μM ndende mu vitro komanso pakuyesa ma cellular.
Mu vivo: IP makonzedwe a SR9011 adagwiritsidwa ntchito pa 100 mg / kg kamodzi kapena kawiri patsiku kwa 12-30.
masiku mumitundu yosiyanasiyana ya mbewa.
Kaphatikizidwe ka SR9009 ndi SR9011
| Kanthu | Kufotokozera | Zotsatira |
| Maonekedwe | Wopanda fungo, pafupifupi ufa woyera kapena woyera | kupita |
| Chizindikiritso | Nthawi yosungira pachimake chachikulu ndi kutsimikizira ku RS | kupita |
| Kutaya pa Kuyanika | Osapitirira 0.5% | 0.33% |
| Kuyesa (HPLC) | Osachepera 99.0% | 99.59% |
| Zotsalira poyatsira | Osapitirira 0.1% | kupita |
| Chitsulo cholemera | Osapitirira 20 ppm | kupita |
Kupaka & Kutumiza
