Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

Nonoreceptor/orphenkephalin FQ (N/OFQ) ndi 17-amino acid neuropeptide yomwe ndi endogenous ligand ya nonoreceptor (ORL-1).Nociceptive peptide, monga mankhwala oletsa ululu, amatha kuthana ndi zotsatira za mankhwala opweteka.Kutsegula kwake kwalumikizidwa ndi ntchito zaubongo monga kumva kupweteka komanso kuphunzira mantha.

Nambala ya chibadwa ya prepronociceptin ili pa munthu Ch8p21.Ma peptide okhudzidwa ndi ululu amachokera ku mapuloteni a peptide a propain, pamodzi ndi ma peptide ena awiri, nocistatin ndi NocII, onse omwe amalepheretsa ntchito ya N / OFQ receptor.Nociceptin anali chitsanzo choyamba cha reverse pharmacology;NOP receptor idapezeka asanatulutsidwe ma endogenous ligands ndi magulu awiri osiyanasiyana mu 1995.

M'maphunziro a nyama, njira yolandirira ya N/OFQ-NOP yapezekanso kuti imagwira ntchito zabwino komanso zoyipa pakuphunzira ndi kukumbukira.Mwachitsanzo, kusokonekera kwa njira iyi kwalumikizidwa ndi kusintha kwamantha kuphunzira muzovuta zaubongo monga post-traumatic stress disorder (PTSD).Chifukwa chake, njira zolandirira zimasunga mayankho a homeostasis ku mantha ndi zovuta.Nociceptor ingathandizenso ntchito yolepheretsa kukumbukira kukumbukira, monga momwe kafukufuku wina asonyezera kuti zimalepheretsa kuphunzira kwa malo mu vivo pamene zimalepheretsa kupititsa patsogolo kwa nthawi yaitali komanso kufalitsa kwa synaptic mu vitro.