Nimetazepam CAS: 2011-67-8 hypnotic tranquilizer

Nimetazepam ndi sing'anga akuchita hypnotic, chochokera benzodiazepine.Idapangidwa koyamba mu 1964 ndi gulu la Hoffmann-La Roche.Imakhala ndi hypnotic yamphamvu, yotsutsa-nkhawa, yodekha komanso yopumula minofu yachigoba."Nimetazepam" ndi yothandiza makamaka anticonvulsant.Amagulitsidwa ngati piritsi la 5-milligram lotchedwa Erimin, dzina lopangidwa ndikugulitsidwa ndi Sumitomo, kampani yayikulu yaku Japan.Japan ndi dziko lokhalo padziko lapansi lomwe limapanga nimetazepam.Kunja kwa Japan, Erimin imapezeka m'madera ambiri a Kum'mawa ndi Kum'mwera chakum'mawa kwa Asia ndipo imagwiritsidwa ntchito kwambiri ngati chithandizo chanthawi yochepa kwa anthu omwe ali ndi vuto la kugona kwambiri omwe amavutika kugona kapena kugona.Sumitomo yasiya kupanga Erimin kuyambira November 2015. Ikupezekabe ngati generic kapena Lavol.

Nimetazepam idalembedwa kwambiri m'ma 1980 ndi 1990, makamaka ku Japan, Malaysia, Brunei, Philippines, Thailand, Indonesia, Hong Kong ndi Singapore.Pokhala ndi nkhanza komanso kuledzera, malangizo a mankhwalawa atsika kwambiri kuyambira 2005. Amagwiritsidwa ntchito makamaka ngati anticonvulsant kwa ana.Amagwiritsidwanso ntchito pazovuta kwambiri komanso zofooketsa za kusowa tulo mu Inpatient Zikhazikiko kapena chithandizo chanthawi yayitali chakunja.Pachifukwa ichi, mapiritsi ogona benzodiazepines Esazolam ndi nitrazepam ankagwiritsidwa ntchito kawirikawiri kuposa nitrazepam.Mankhwala oletsa kupsinjika maganizo monga trazodone ndi mirtazapine kapena Zopiclone ndi zolpidem ndi mankhwala oyamba a kusowa tulo.

Ngakhale kuti mankhwala a nimetazepam achepa, kugwiritsa ntchito mankhwala osokoneza bongo kumakhalabe kwakukulu ku Brunei, Singapore, Malaysia ndi Philippines.Amagwiritsidwa ntchito kwambiri kuphatikiza ndi methamphetamine ndi ecstasy, komanso opioid (makamaka heroin kapena morphine).Nimetazepam ili ndi malamulo okhwima ovomerezeka ku Malaysia, zomwe zapangitsa kuti mankhwalawa akhale ochepa, koma mapiritsi ambiri omwe amagulitsidwa pamsika wakuda pansi pa dzina la Nimetazepam ndi abodza.Diazepam ndi nitrazepam ndi ena mwa benzodiazepines omwe amagwiritsidwa ntchito kwambiri m'derali, ndipo motero, amapatutsidwa ndikugulitsidwa pamsika wakuda, nthawi zambiri monga nitrazepam.

Kupanga kosaloledwa kwa Nimezepam (kugulitsidwa ngati Erimin-5) kwafalikira m'derali.Kuzunza kwa nimetazepam kunapitilira kukula m'ma 2010.Kugwidwa kwa mapiritsi opangidwa mosaloledwa ndi Erimin-5 kunachitika limodzi ndi kukomoka kwa methamphetamine ku Malaysia.Mapiritsi ochepera 46 a Erimin-5 omwe adagwidwa adayesedwa kuti ali ndi thupi komanso mankhwala.Zomwe zimagwiritsidwa ntchito, dopant, diluent choyambirira, ndi utoto ndizomwe zimapangidwira piritsilo.Zotsatira zake zidawonetsa kuti Nimetazepam ndiyomwe imagwiritsidwa ntchito kwambiri pamapiritsi ambiri omwe adagwidwa.Lactose adadziwika kuti ndiye wowonjezera kwambiri m'masampuli ambiri, kenako mannitol kenako dicalcium phosphate dihydrate.Dzuwa lalowa chikasu chinapezeka m'mapiritsi ambiri, omwe amagwiritsidwa ntchito okha kapena ophatikizana ndi utoto wina (monga tartar ndi Lichenol 4R) kuti apatse piritsilo mtundu wa pichesi/lalanje.Mapiritsi obiriwira pachitsanzocho anali ndi utoto wowala wabuluu ndi tartar.Diazepam kwenikweni ndi mankhwala oletsa nkhawa ndipo ndizomwe zimagwira pamapiritsi 46 okha.Nitrazepam, sedative yamphamvu ndi hypnotic ndi mankhwala a makolo a nitrazepam, adapezeka kuti ndi gulu lachiwiri, ndi caffeine kukhala chigawo chachikulu chophatikizidwa m'mapiritsi atatu.

Mu 2003, Singapore inalanda mapiritsi 94,200 a Erimin-5.Laborator ya Central Narcotics Board (CNB) idayesa mapiritsiwo ndipo zotsatira zake zidatsimikizira kuti analidi nitrazepam.