Zambiri zowonjezera zotsutsana ndi ukalamba

Mutu wotsutsa kukalamba wakhala wotchuka kwambiri m'zaka zaposachedwa, ndi maphunziro osiyanasiyana akutuluka kosatha.
Nthawi ndi nthawi, gulu lina lofufuza limapeza chinthu choletsa kukalamba chomwe chingatithandize kukhala ndi moyo zaka zana.
Anthufe timakhala ndi malire a moyo wa zaka 150, chifukwa ma telomere amafupikitsa pang'ono zaka ziwiri kapena zitatu zilizonse, ndipo maselo amatha kugawikana pafupifupi ka 50, akutero Hafrick wa telomere Theory.
Palinso akatswiri ena omwe ali ndi chiyembekezo akuti: munthu woyamba kukhala ndi moyo zaka 1000, wabadwa, m'dziko lathu lapansi, mwina ndiwe.
Ndi chitukuko cha biomolecular biology, tsiku lina tikhoza kupeza matsenga omwe angatithandize kukhala ndi moyo wautali.
Chifukwa chake, khalani athanzi, gwirani ntchito molimbika kuti mupange ndalama, ndikudikirira kuti ukadaulo ukhwime tsiku lina, mwina, mutha kukhala ndi moyo wautali.
Lero, ndikudziwitsani zina mwazinthu zowonjezera zoletsa kukalamba zomwe zimadziwika, ndipo yang'anani zochepa zomwe mwaziwona.

1. Epitalon

Epitalon ndi peptide yoletsa kukalamba, yopangidwa kuchokera ku amino acid chain alanine-glutamine-asparagine-glycine, yomwe imakweza ntchito ya telomerase m'thupi kuti ithandize kuchepetsa ukalamba.

Ma telomere ali ngati zipewa zolimba zomwe zimateteza DNA.Ma chromosome ambiri m'thupi amakhala ndi ma telomere kumapeto onse awiri;Ntchito yaikulu ya telomerase ndikuthandizira kusunga kutalika kwa ma telomere m'thupi.

Matenda ena amagwirizanitsidwa ndi ma telomere amfupi, omwe amachititsa kuti azikalamba mofulumira;Epitalon ikhoza kugwiritsidwa ntchito pochiza matenda omwe amayambitsa kukalamba msanga, monga Bloom syndrome ndi Werner syndrome.

Epitalon imathandizanso kuchepetsa chiopsezo cha matenda okhudzana ndi kusowa kwa telomerase, monga matenda a shuga, chifukwa kutulutsa kwa insulini kumaletsedwa ndi kusowa kwa telomerase.

Peptide ingakhalenso ndi zotsatira zabwino pa thanzi la mtima ndipo ingathandize kupewa matenda a mtima;Asayansi akufufuza momwe angathere pochiza zotupa.

2: Kukumini

Turmeric ndi chakudya chambiri cha ku India, ndipo curcumin ndizomwe zimaphunziridwa kwambiri mu turmeric, zomwe zimakhala ndi anti-inflammatory and antioxidant properties.

Kafukufuku wasonyeza kuti curcumin imatsegula ma sirtuins (deacetylases) ndi AMPK(AMP-activated protein kinase), omwe amathandiza kuchepetsa kukalamba kwa maselo ndi kutalikitsa moyo.

Kuonjezera apo, curcumin yasonyezedwa kuti ikulimbana ndi kuwonongeka kwa maselo ndikuwonjezera kwambiri moyo wa ntchentche za zipatso, zozungulira, ndi mbewa;Zingathenso kuchedwetsa kuyamba kwa matenda okhudzana ndi ukalamba ndi kuchepetsa zizindikiro za matenda okhudzana ndi ukalamba

3: cannabinoid

Zomwe zimagwiritsidwa ntchito pa chamba, zomwe zimadziwika kuti cannabinoids, ndi gulu la mankhwala a terpenoid phenolic, omwe amadziwika kwambiri ndi tetrahydrocannabinol (THC) ndi cannabidiol (CBD).

CBD imatha kulimbana ndi ma free radicals m'maselo a khungu, kukhala ngati antioxidant komanso anti-aging agent.Nthawi zambiri amawonjezeredwa kuzinthu zosamalira khungu ndipo nthawi zambiri amagwiritsidwa ntchito kuti athetse ululu wosatha, ndi zotsatira zabwino

4: spermidine

Spermidine ndi gawo lachilengedwe la umuna, ndipo matupi athu (amuna ndi aakazi) amangotulutsa gawo limodzi mwa magawo atatu a umuna, ndipo zina zonse zimachokera ku zakudya zathu.

Zakudya zake zimaphatikizapo: tchizi wakale, bowa, natto, tsabola wobiriwira, nyongolosi ya tirigu, kolifulawa, broccoli, ndi zina zambiri.

Anthu aku Asia ali ndi kuchuluka kwa asidi arginous muzakudya zawo, zomwe zitha kukhala zokhudzana ndi moyo wawo wautali.

Kafukufuku wa spermidine akukula m'zaka zaposachedwa, ndipo zapezeka kuti zili ndi zotsatirazi:

Wonjezerani moyo wathanzi;

Kupititsa patsogolo chidziwitso cha okalamba;

Mphamvu ya neuroprotective;

Kuchepetsa kufa kwa zifukwa zonse;

Kutsika kwa magazi;

yambitsani autophagy ndi kuchedwa senescence;

Zimapangitsa tsitsi kukula mofulumira komanso misomali yamphamvu.

5: thupi la ketone

Chimodzi mwazifukwa zazikulu za zakudya za ketogenic ndizotchuka ndikuchepetsa thupi komanso kumveka bwino kwamaganizidwe.

Thupi likayamba kuwotcha mafuta amthupi, limapanga matupi a ketone, omwe amapereka mphamvu zoyera ku ubongo ndikuwongolera magwiridwe antchito ake.

Ma Ketoni ali ndi zotsutsana ndi ukalamba, ndipo kafukufuku wapeza kuti BHB (beta-hydroxybutyric acid) ikhoza kulimbikitsa kugawanika kwa maselo, kuteteza kukalamba kwa maselo, ndi kusunga mitsempha ya magazi ndi ubongo wachinyamata.

Thupi limatha kupanga matupi a keto popewa ma carbohydrate, kapena limatha kutenga zowonjezera za keto kuti lifulumizitse njirayi ndikuchepetsa kupweteka kwa kusinthako, komwe kumadziwika kuti "keto flu."

Zakudya za Ketogenic, kapena kumwa mankhwala owonjezera a keto, zimatha kuchedwetsa kukalamba, kupititsa patsogolo chidziwitso, ndikuthandizira kupewa matenda a neurodegenerative monga Alzheimer's.

6: Dasatinib

Tikamakalamba, maselo athu ena amazemba chitetezo chamthupi.Maselo “otsala” amenewa sachita zimene ankayenera kuchita, koma amawotcha mphamvu.

Maselo oterowo "zakudya zonse komanso osagwira ntchito", omwe amadziwikanso kuti "maselo a zombie", kapena ma cell a senescent, amaunjikana pakapita nthawi, zomwe zimapangitsa kuti thupi lizigwira ntchito bwino.

Kusala kudya, kuchita masewera olimbitsa thupi komanso kukhala ndi moyo wathanzi kumayambitsa autophagy, yomwe imatsuka ma cell a zombie.

Dasatinib, mankhwala a chemotherapy omwe amagwiritsidwa ntchito pochiza khansa ya m'magazi, amathanso kuchotsa bwino maselo amafuta okalamba ndikuchepetsa kutulutsa kwa ma cytokines oyambitsa kutupa mu minofu ya adipose.

Ndiwo mankhwala oyamba a Senolytics omwe apezeka, mankhwala omwe amachotsa ma cell a senescent mwa kusokoneza njira zowonetsera ma cell a senescent, ndikulepheretsa kwakanthawi ma SCaps (njira zotsutsana ndi apoptotic).

Zinthu zomwe zimatha kuchotsa ma cell a senescent ndi PCC1 kuchokera ku Chinese Academy of Sciences, komanso zinthu zina monga quercetin.