Chiyambi cha Somaglutide
Somaglutide ndi m'badwo watsopano wa GLP-1 (glucagon ngati peptide-1) analog yopangidwa ndi Daminol ndi NovoNordisk.Somaglutide ndi mawonekedwe anthawi yayitali omwe amapangidwa kutengera kapangidwe ka Lilalutide, komwe kumakhudza bwino chithandizo cha matenda amtundu wa 2.Novo Nordisk wamaliza maphunziro a 6 PChemicalbookbaseIIIa pa jekeseni wa Somaglutide, ndipo adapereka ntchito yatsopano yolembera mankhwala kwa jekeseni wa mlungu ndi mlungu wa Somaglutide ku US Food and Drug Administration (FDA) pa December 5, 2016, komanso ntchito yogulitsa malonda (MAA) European Drug Autsogoleri (EMA).Kumbali inayi, kukonzekera pakamwa kamodzi pa tsiku kwa Somaglutide pakalipano mu gawo lachipatala III.
Kugwiritsa ntchito
Somaglutide ndi mawonekedwe anthawi yayitali opangidwa kutengera kapangidwe ka liraglutide, yomwe imakhala ndi zotsatira zabwino pochiza matenda amtundu wa 2.
Kafukufuku
Semeglutide ndi analogi watsopano wa GLP-1 yemwe amabayidwa pansi pakhungu kamodzi pa sabata.Somaglutide ndi analogue ya GLP-1 yanthawi yayitali yopangidwa ndi Novo Nordisk kwa nthawi imodzi / w jekeseni wa subcutaneous.Poyerekeza ndi liraglutide, Somaglutide ili ndi unyolo wautali wamafuta komanso kuchuluka kwa hydrophobicity.Komabe, Somaglutide imasinthidwa ndi PEG yochepa, ndipo hydrophilicity yake imakula kwambiri.Pambuyo pa kusintha kwa PEG, sikungangophatikizana kwambiri ndi albumin, kuphimba malo a hydrolysis a DPP-4 enzyme, komanso kuchepetsa kutulutsa kwaimpso, kutalikitsa theka la moyo ndikupeza zotsatira za kuzungulira kwautali.Novo Nordisk's Somaglutide anapachika DPP-4's Sigliptin, ndi GLP-1's woyambitsa, exenatide yaitali (iyenera kupangidwa kuti ipikisane mutu ndi mutu ndi trucity ya Lily. Kupezerera kwakhala pa msika kwa nthawi yaitali).Poyesera, mlingo waukulu wa Somicalbook unatsika A1C1.6%, ndipo kuchepa kwakukulu kunali 6 kg.Somaglutide idagwiritsidwa ntchito pofufuza momwe 1.0mg Somaglutide imagwirira ntchito poyerekeza ndi 2.0mg Exenatide kamodzi pa sabata mwa odwala 813 omwe ali ndi matenda a shuga a 2.Nthawi yoyeserera inali masabata 56, ndipo odwala adamwa 1-2 mankhwala oletsa matenda a shuga pakamwa nthawi yomweyo.Mu Disembala 2017, FDA idavomereza mwalamulo mankhwala a GLP-1 a hypoglycemic a Somaglutide opangidwa ndi NovoNordisk kuti azigulitsidwa pansi pa dzina la malonda Ozempic.Malinga ndi kafukufuku wazachipatala, Ozempic imatha kuchepetsa mulingo wa HbA1c poyerekeza ndi placebo, Januvia waku Merck, Bydureon waku AstraZeneca ndi Lantus waku Sanofi.Mankhwalawa adawonetsanso mphamvu zothandizira odwala kuti achepetse thupi.
Nthawi yotumiza: Dec-25-2022