Clobetasol propionate akhoza kuchiza psoriasis?Matenda onse apakhungu?

Clobetasol propionateakhoza kuchiza psoriasis.

Mawu ofanana ndi mawu:

17-propionate;cgp9555;Clobetasol 17-propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-dione; CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R) -17-(2-chloroacetyl) -9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate

Kagwiritsidwe:

Clobetasol Propionatendi mchere wa propionate wa clobetasol, topical synthetic corticosteroid yokhala ndi anti-inflammatory, anti-pruritic, ndi vasoconstrictive properties.Clobetasol propionate imakhala ndi zotsatira zake pomanga ma cytoplasmic glucocorticoid receptors ndipo kenako imayendetsa glucocorticoid receptor mediated gene expression.Izi zimabweretsa kuphatikizika kwa mapuloteni ena oletsa kutupa, pomwe amalepheretsa kaphatikizidwe ka oyimira pakati otupa.Makamaka, clobetasol propionate ikuwoneka kuti imapangitsa kuti phospholipase A2 inhibitory mapuloteni, potero imayang'anira kutulutsidwa kwa arachidonic acid yotupa kuchokera ku membrane phospholipids ndi phospholipase A2.

Clobetasol propionate ndi 17-O-propionate ester ya clobetasol ndipo imachokera ku clobetasol ndi propionic acid.Ndi corticosteroid yamphamvu, imagwiritsidwa ntchito pochiza matenda osiyanasiyana a khungu, kuphatikizapo exzema ndi psoriasis.
Clobetasol propionate inali yovomerezeka mu 1968 ndipo inayamba kugwiritsidwa ntchito pachipatala mu 1978. Imapezeka ngati mankhwala a generic.Clobetasol propionate amagwiritsidwa ntchito pochiza matenda osiyanasiyana a khungu kuphatikizapo chikanga, herpes labialis, psoriasis, lichen sclerosus.Amagwiritsidwanso ntchito pochiza matenda angapo a auto-immune, kuphatikizapo alopecia areata, lichen planus (auto immune skin nodules), ndi mycosis fungoides (T-cell skin lymphoma).Amagwiritsidwa ntchito ngati chithandizo choyambirira cha GVHD yapakhungu komanso yachikazi. kapena hyperplastic matenda.Ndiwopanga fluorinated corticosteroid.Zitha kuyambitsa kuyankha mwachangu kapena kwanthawi yayitali kuposa ma topical corticosteroids ena.Ndibwino kuti clobetasol ikhale yogwiritsidwa ntchito kwambiri ndi 60 g / sabata kwa masiku osapitirira 14 popanda kutsekedwa komanso kuti sayenera kugwiritsidwa ntchito kwa ana osakwana zaka 12.

A njira ya betamethasone 21-methanesulfonate (4 g) mu dimethylformamide (25 ml) ankachitira ndi lithiamu kolorayidi (4 g) ndi osakaniza mkangano pa nthunzi kusamba kwa mphindi 30.Kusungunula ndi madzi kunapatsa zinthu zosakayikitsa zomwe zidapangidwanso kuti zitheke kutengera mutuwo, MP 226 ° C.
Clobetasol nthawi zambiri imasinthidwa kukhala propionate ngati mawonekedwe othandiza pochita ndi propionic anhydride.