NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

NPFF Neuropeptide (FLFQPQRFa) ndi mammalian aminated neuropeptide yomwe idadzipatula ku ubongo wa ng'ombe ndipo imadziwika ngati peptide yoletsa kupweteka yokhala ndi antiopioid kupita ku morphine-induced analgesia.

Mwa anthu, neuropeptide FF peptide imasungidwa ndi jini ya NPFF.Majini awiri omwe ali ndi ma receptor awiri osiyana (NPFF1 ndi NPFF2) ndi ma precursors awiri (NPFFA ndi NPFFB) adapangidwa mu nyama zingapo zoyamwitsa.

Neuropeptide FF (NPFF) ndi ma peptide okhudzana ndi RFamide opangidwa ndi otsogolera awiri amalumikizana ndi magulu awiri a G-protein-coupled receptors, NPFF1 ndi NPFF2 subtypes, omwe ali ndi chiyanjano chabwino ndipo amakhudzidwa ndi ntchito zosiyanasiyana za thupi, monga kulamulira mtima kwa mtima, Kuwongolera kwa mahomoni, kuyambitsa kwa macrophage, thermohomeostasis, komanso kuchepetsa ululu.

Chithandizo cha kalambulabwalo wa NPFFA pamalo oyambira proteolytic akuyenera kutulutsa peptide yomwe ili ndi NPFF, yokhala ndi ma amino acid atatu owonjezera a N-terminal omwe amasiyana mitundu ndi mitundu, ndi peptide yomwe ili ndi NPSF (SLAAPQRFa), yomwe kutalika kwake kumadalira zamoyo.NPFFB yadziwika kuti ndi kalambulabwalo wa peptide yokhudzana ndi RFamide (RFRP, yomwe imadziwikanso kuti GnIH ya gonadotropin-suppressing hormone), yomwe ili ndi ma peptides omwe ali ndi LPLRFa ndi ma peptides omwe amagawana nawo C-terminal PQRFamide motif monga NPFF, monga NVPF (VPNLPQRFa) munthu.

NPFF ndi machitidwe a opioid awonetsedwa kuti amalumikizana pamagulu angapo, kuchokera ku khalidwe la nyama kupita ku mamolekyu olandirira.Nociception ndi ntchito yophunzira kwambiri ya thupi la kuyanjana uku, koma mphotho, kuyenda, kudya ndi matumbo zimakhudzidwanso.Ma opioid amkati amafunikira kuti azitha kutulutsa jekeseni wa msana wa NPFF, ndipo ma peptide a NPFF amkati amakhudzidwa ndi kulekerera kwa analgesic / hyperalgesia yoyambitsidwa ndi mankhwala opioid osatha.

NPFF imayang'aniranso kuchuluka ndi kagayidwe ka macrophages mu minofu ya adipose, yomwe ndiyofunikira pa thanzi la minofu ya adipose.