Zopanga zopanga Dihexa CAS 1401708-83-5

Kagwiritsidwe:

DIHEXA (PNB-0408), reagent oligoplase, ndi analogue ya IV ya vascular tensionin IV yokhala ndi zochitika zapakamwa komanso zotchinga zamagazi ndi ubongo.Dihexa wochezeka kwambiri ndi mphamvu amaphatikiza hepatocyte kukula factor (HGF), ChemicalBookkd mtengo ndi 65PM, ndipo imawonjezera ntchito yake kuti ilandire C-MET.Dihexa imawonetsa ntchito yabwino kwambiri yoletsa kutulutsa umuna ndikuwongolera magwiridwe antchito azidziwitso mumitundu yanyama.Dihexa ali ndi kuthekera kophunzira matenda a Alzheimer's.

Dihexa imamanga ndi kuyanjana kwakukulu kwa HGF ndi dihexa ndi kholo lake Norleucine 1-AngIV imapangitsa c-Met phosphorylation pamaso pa subthreshold woipa wa HGF ndi augment HGF amadalira cell kubalalitsa.Kupitilira apo, dihexa ndi Nle1-AngIV imapangitsa hippocampal spinogenesis ndi synaptogenesis yofanana ndi HGF yokha.Dihexa imalepheretsa bwino HGF dimerization pa 1 μM. Pomwe dihexa pa 1 nM ndi 10 pM yokha siyambitsa c-Met, imathandizira kwambiri mphamvu ya HGF pa 1.25 ndi 2.5 ng / mL kuti iyambitse c-Met.

Dihexa ali ndi moyo wautali wozungulira.Dihexa imawonetsa zochitika zodziwikiratu.Imawongolera kuphunzira kwapapata mu makoswe okalamba.Dihexa imapangitsa kuti ma spinogenesis apangidwe mu hippocampal neurons.