High Purity pharmaceutical intermediates β-Nicotinamide Mononucleotide CAS:1094-61-7 Mayendedwe otetezeka kuti atsimikizire chilolezo

Zogulitsa

Ntchito
β-Nicotinamide mononucleotide (NMN) imagwiritsidwa ntchito pophunzira zomangira zomangira mkati mwa ma aptamers a RNA ndi njira zotsegulira za ribozyme zomwe zimaphatikizapo β-nicotinamide mononucleotide (β-NMN) -zidutswa za RNA zoyambitsa.NMN ndi nucleotide yochokera ku ribose ndi nicotinamide.Niacinamide (nicotinamide,) ndi wochokera ku vitamini B3, wotchedwanso niacin.) Monga kalambulabwalo wa biochemical wa NAD +, ingakhale yothandiza popewa pellagra.
β-Nicotinamide mononucleotide ndi wapakatikati mu biosynthesis ya nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) imathandizira kusungunuka kwa nicotinamide ndi 5-phosphoribosyl-1-pyrophosphate kupanga β-NMN, yomwe pambuyo pake imasinthidwa kukhala NAD+ ndi β-NMN adenyltransferase. NAD biosynthesis ndi glucose-stimulated insulin secretion mu Nampt +/- mouse model of metabolic matenda, kusonyeza udindo wa Nampt mu β cell function. Komanso, pa 500 mg/kg/tsiku, zasonyezedwa.

Zina

Nicotinamide mononucleotide ("NMN" ndi" β- NMN ") ndi nucleotide yochokera ku ribose, Nicotinamide, Nicotinamide nucleoside ndi nicotinic acid. Mwa anthu, ma enzyme ambiri amagwiritsa ntchito NMN kupanga Nicotinamide adenine dinucleotide, NADH was Inproposed). kuti NMN idalowetsedwa m'matumbo ang'onoang'ono mkati mwa mphindi za 10 pambuyo poyang'anira pakamwa ndikusinthidwa kukhala Nicotinamide adenine dinucleotide (NAD +) kudzera mu transporter ya Slc12a8.

Chifukwa NADH kukhala cofactor wa mitochondrial mkati njira, sirtuins, ndi PARP, NMN yaphunziridwa ngati angathe neuroprotective ndi anti-kukalamba wothandizira mu zitsanzo nyama.Miyezo ya NAD + ikawonjezeka, kuletsa kuwonongeka kwa mitochondrial kumatha kusintha ukalamba pama cell a cell, ndikupangitsa kuti ikhale yotchuka kwambiri pazinthu zotsutsana ndi ukalamba.Makampani owonjezera zakudya amalimbikitsa mwachangu zinthu za NMN, kunena kuti ali ndi zopindulitsa izi.Komabe, mpaka pano, sipanakhalepo kafukufuku waumunthu kuti atsimikizire molondola zotsatira zake zotsutsa kukalamba.Kafukufuku wa Keio University akuwonetsa kuti mlingo umodzi wa 500 mg ndi wotetezeka kwa amuna.Mu 2021, mayeso azachipatala adapeza kuti NMN idathandizira kukhudzidwa kwa insulin ya amayi omwe ali ndi matenda a shuga, pomwe mayeso ena azachipatala adapeza kuti adakulitsa luso la aerobic la othamanga osasewera.

NMN imakhudzidwa mosavuta ndi kuwonongeka kwa extracellular ndi ma CD38 enzymes, omwe amatha kuletsedwa ndi mankhwala monga CD38-IN-78c.