High Purity Pharma API CAS14769-73-4 Hydrochloride Levamisole Base
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Zambiri Zoyambira
Tanthauzo
A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole yomwe ili ndi S kasinthidwe.Amagwiritsidwa ntchito (kawirikawiri ngati mchere wa monohydrochloride) pochiza matenda a nyongolotsi za nkhumba, nkhosa ndi ng'ombe ndipo poyamba ankagwiritsidwa ntchito pothandizira mankhwala a chemotherapy pofuna kuchiza khansa zosiyanasiyana.Amagwiritsidwanso ntchito kwambiri ngati chigololo ku coccaine.
Zizindikiro
Levamisole (Ergamisol) ndi mankhwala oletsa tizilombo toyambitsa matenda omwe apezeka kuti apititse patsogolo ntchito ya T-cell ndi chitetezo cha mthupi.The mankhwala bwino kupulumuka kwa odwala resected colorectal khansa pamene pamodzi 5-fluorouracil;njira ya kuyanjana uku sikudziwika.Levamisole alibe antitumor ntchito motsutsana kukhazikitsidwa kapena metastatic khansa ndipo sanapezeke zothandiza mu adjuvant mankhwala a khansa ena kuposa colorectal khansa.
Zotsatira zazikulu za levamisole ndi nseru ndi anorexia.Ziphuphu pakhungu, kuyabwa, zizindikiro za chimfine, ndi kutentha thupi kwawonedwanso.
Zizindikiro
Levamisole (Ergamisol) poyamba anapangidwa monga antihelminthic mankhwala.Imawonjezera zotsatira zolimbikitsa za ma antigen, mitogens, lymphokines, ndi chemotactic factor pa ma lymphocytes, granulocytes, ndi macrophages.Zawonetsedwa kuti zimawonjezera chitetezo chamthupi cha T cell.
Levamisole wakhala akugwiritsidwa ntchito bwino pochiza matenda aakulu.Yavomerezedwanso kuti igwiritsidwe ntchito limodzi ndi fluorouracil pochiza khansa yapakhungu.
Kugwiritsa ntchito
Ntchito Biological response modifier.
Ntchito Levamisole ntchito koyamba ndi yachiwiri immunodeficient zinthu, autoimmune matenda, aakulu ndi reoccurring matenda, lalikulu intestine adenocarcinoma, helmintosis, ndi nyamakazi.Mafananidwe a mankhwalawa ndi decaris, tetramizole, ndi ena.
Levimasole ndi mankhwala osankhidwa a ascardiasis.Kafukufuku wambiri akuwonetsa kuti mlingo umodzi wa levamisole umachiritsa 90 mpaka 100% ya odwala ascardiasis, makamaka omwe ali ndi A. duodenale.Ndiwochepa kwambiri polimbana ndi ancylostomiasis ndi strongyloidiasis.Komabe, sizothandiza motsutsana ndi N. americanus.Zikuoneka kuti ili ndi mphamvu ya gangliostimulating pamatenda a parasympathetic komanso achifundo.Komanso, zikuganiziridwa kuti mankhwalawa ali ndi immunomodulatory zotsatira pa khamu chamoyo.Mafananidwe a mankhwalawa ndi decaris, solacil, ergamisol, tramisol, immunol, ndi ena.
Kugwiritsa Ntchito Zachipatala
Ascariasis Hookworm matenda
Levamisole yakhala ikugwiritsidwa ntchito mu nyamakazi ya nyamakazi ndi zina zomwe zimanenedwa kuti zimayankhira ntchito yake ya immunomodulatory.
Ntchito Yochizira
Antiinflammatory
Antimicrobial ntchito
Ntchito yake yayikulu ikutsutsana ndi Asc.lumbricoides ndi hookworms.Nyongolotsi zimafa ziwalo ndipo zimatuluka mu ndowe mkati mwa maola ochepa.
Ntchito Zamankhwala
L-isomer ya tetramisole, yomwe imapezeka ngati monohydrochloride.D-isomer ilibe mankhwala anthelmintic.Ndilosungunuka kwambiri m'madzi ndipo ndi lokhazikika pakauma.
Njira yochitira
Levamisole ali ndi immunomodulating ntchito.Amakhulupirira kuti imayang'anira ma cell a chitetezo chamthupi, komanso momwe zimagwirira ntchito zimatha kulumikizidwa ndi kuyambitsa komanso kukula kwa T-lymphocytes, kuchuluka kwa ma monocytes ndi kutsegula kwa macrophages, komanso ndi kuchuluka kwa ntchito ndi hemotaxis ya neutrophylic. ma granulocytes.Levamisole imawonetsanso zochita za anthelmin.Zimawonjezeranso mphamvu ya thupi lonse ndikubwezeretsanso T-lymphocyte ndi phagocyte kusintha.Ikhozanso kukwaniritsa ntchito ya immunomodulatory mwa kulimbikitsa kufooka kwa chitetezo cha m'maselo, kufooketsa mphamvu yamphamvu, komanso kukhalabe ndi mphamvu pazochitika zachibadwa.