GW-0742 SARMs Ufa |GW610742 CAS 317318-84-6
Kugwiritsa ntchito
Kwa kunenepa kwambiri, matenda a shuga, dyslipidemia ndi matenda amtima Mankhwala oyesera amatanthauza kulamulira lipids ndi kuonjezera mlingo wa HDL, kapena cholesterol yabwino, m'magazi.Ma cell-permeable, thiazolyl pawiri omwe amakhala ngati amphamvu, ogwirizana kwambiri, PPARδ agonist.Amawonetsa kusankha kwa PPARδ poyerekeza ndi PPARα ndi PPARγ.Simatuluka pazochitika zilizonse motsutsana ndi ma nyukiliya ena kapena omwe si a nyukiliya.Amanenedwa kuti amachulukitsa cholesterol efflux ndi ABAC1 mawu mu macrophages, fibroblasts, ndi ma cell am'mimba.
Cardarine amagwiritsidwa ntchito ndi othamanga omwe amapikisana pamasewera osiyanasiyana.Mwachitsanzo, othamanga opirira atha kuwonjezera chipiriro cholimbitsa thupi mwa kuyika PPAR iyi ndi mankhwala a analogi a AMP AICAR, kapena kuthamanga cardarine solo.Zotsatira zake, adzakhala ndi mwayi wofikira ma RPM apamwamba panthawi yothamanga popanda kugunda kugunda kwamtima.Izi zilola wothamanga/wanjinga/wosambira kuti azibera kugunda kwamtima kwawo kwanthawi yayitali ndikupita nthawi yayitali osawombedwa ndi mphepo, zomwe zimapangitsa kuti stack iyi ikhale chida chodabwitsa chogwiritsa ntchito pamasewera opirira.Kwenikweni, kuchokera pazomwe ndakumana nazo ndikutha kudziwa kuti cardarine ikhoza kugogoda pa masekondi 30-45 kuchoka pa nthawi ya 5K ngati ikugwiritsidwa ntchito kutsogolera mpikisano.
Kufotokozera
MAWU OFUNIKA:Kutaya mafuta, kupirira, kusakhala ndi zotsatirapo zoyipa, omanga thupi, chithandizo cha kunenepa kwambiri kuphatikiza kumathandizira kukhalabe wowonda, kumawonjezera minofu.
Cardarine (GW-501516) imayikidwa m'gulu la SARMS, komabe mwadongosolo ndi kutanthauzira, ndi PPAR modulator.Monga PPAR modulator, imayambitsa AMP-activated protein kinase ndipo imapangitsa kuti glucose atengeke mu minofu ya chigoba.GW-501516 ili ndi luso lotha kusintha mavuto a metabolism polimbikitsa mafuta acid oxidation.Amaonedwa ngati chithandizo champhamvu cha kunenepa kwambiri komanso zinthu zina zofananira.
GW501516 ndi dzina la mankhwala a Glaxo Wellcome (GW imayimira kampaniyo ndipo chiwerengero chake ndi cha mankhwala).Amadziwikanso kuti GW-501,516, GW1516, GSK-516).Ndi PPARδ receptor agonist yomwe sinatengedwe patsogolo kuposa mayesero azachipatala.Momwemo ndizoletsedwa pamasewera.Ikukwanira m'malo angapo pamndandandawo, kuphatikiza makamaka ngati ma agonists a "peroxisome Proliferator Activated Receptor δ (PPARδ) (monga GW501516)".Koma ikhalanso pansi pa gawo latsopano la WADA "zosavomerezeka" zomwe cholinga chake ndi kuletsa mankhwala aliwonse opanda chilolezo omwe amagwiritsidwa ntchito ndi osewera.
GW501516 (yomwe imadziwikanso kuti GW-501,516, GW1516, GSK-516) ndi PPAR & receptor agonist yomwe idapangidwa mogwirizana pakati pa Ligand Pharmaceuticals ndi GlaxoSmithKline m'ma 1990s, idalowetsedwa mu chitukuko chachipatala ngati ofuna kudwala matenda a metabolic ndi mtima. , ndipo anasiyidwa mu 2007 chifukwa kuyesa nyama kunasonyeza kuti mankhwalawa amachititsa kuti khansa iyambe kukula mofulumira m'magulu angapo.
Mu kafukufuku wa 2007 adasindikizidwa kusonyeza kuti mlingo waukulu wa GW501516 woperekedwa kwa mbewa umapangitsa kuti thupi lawo likhale labwino kwambiri;ntchitoyo inakambidwa mofala m'ma TV otchuka, ndipo inachititsa kuti msika wakuda kwa ofuna mankhwala osokoneza bongo komanso kuzunzidwa ndi othamanga monga doping wothandizira.
Mapulogalamu
GW501516 ikhoza kugwiritsidwa ntchito ndi othamanga ngati mankhwala owonjezera a ergogenic omwe sankalamulidwa ndi malamulo kapena kuzindikiridwa ndi mayesero ovomerezeka.M'modzi mwa ochita kafukufuku wamkulu pa kafukufuku wopitilira kupirira adapanga mayeso a mkodzo kuti azindikire mankhwalawa, ndikupangitsa kuti apezeke ku International Olympic Committee.
GW imathandizira kutengeka kwa glucose komanso minofu yamafupa.Amawotcha mafuta polimbikitsa mafuta acid oxidation.Amaganiziridwa ngati chithandizo chothandizira kunenepa kwambiri chifukwa amatha kusungunula mafuta mwachangu.Komanso, Cardarine akuti akuwonjezera HDL ndi pafupifupi 79% (cholesterol yabwino) ndi kuchepetsa LDL (cholesterol choipa) m'mayesero apano a Phase II.GW 501516 ndi PPARδ agonist.Izi zimathandizira kukulitsa milingo yanu ya HDL kuchokera pamawu owonjezera a chonyamulira cha cholesterol ABCA1.
GW imathandizira kutengeka kwa glucose komanso minofu yamafupa.Amawotcha mafuta polimbikitsa mafuta acid oxidation.Amaganiziridwa ngati chithandizo chothandizira kunenepa kwambiri chifukwa amatha kusungunula mafuta mwachangu.Komanso, Cardarine akuti akuwonjezera HDL ndi pafupifupi 79% (cholesterol yabwino) ndi kuchepetsa LDL (cholesterol choipa) m'mayesero apano a Phase II.GW 501516 ndi PPARδ agonist.Izi zimathandizira kukulitsa milingo yanu ya HDL kuchokera pamawu owonjezera a chonyamulira cha cholesterol ABCA1.
Kupaka & Kutumiza
