Glucagon CAS: 16941-32-5 Glucagon (1-29) Munthu HCl GLUCAGON 1-37

Glucagon, yomwe imadziwikanso kuti hyperglycemin ndi glucagon, ndi mahomoni a polypeptide owongoka omwe amapangidwa ndi ma cell a α a pancreatic islet, okhala ndi 29 amino acid.Mapangidwe ake a maselo ndi kulemera kwake kwa maselo ndi C153H225N43O49S = 3482.8.Hormoni iyi yapangidwa m'dziko langa.White wabwino crystalline ufa pa firiji, odorless, zoipa.Sasungunuke m'madzi ndi zosungunulira zambiri za organic, sungunuka mu asidi wosungunuka ndikusungunula lye.Zokonzekera zambiri zimapangidwa ndi hydrochloride yake, yomwe imasungunuka m'madzi.Tsopano zikudziwika kuti glucagon iyenera kusunga umphumphu wake wa maselo kuti agwiritse ntchito thupi lake.Mapangidwe a hyperglycemic amatha kukhala osasinthasintha mwa anthu ndi zoyamwitsa (akalulu, ng'ombe, nkhumba, makoswe, ndi zina), koma mosiyana pang'ono ndi mbalame.Ndikofunikira kwambiri kuti mukhale ndi shuga wabwinobwino m'magazi.Ntchito yake yayikulu ndikuyambitsa phosphorylase mu myocardium, kulimbikitsa kuwonongeka kwa glycogen ndikukhala ndi zotsatira ngati catecholamin.Chifukwa chake, imakhala ndi mphamvu yamtima pamtima, kukulitsa kugunda kwa mtima, kugunda kwamtima komanso kuthamanga kwa magazi.Cardioenhancement si limodzi ndi kuwonjezeka mtima excitability, koma kuonjezera calcium ayoni mu cardiomyocytes ndipo akhoza yambitsa adenosine cyclase pa chiwindi cell nembanemba mu Chemicalbook, kulimbikitsa synthesis cyclic adenosine mankwala mu maselo.Glucagon idanenedwa kuti ndiyothandiza nthawi zina za kulephera kwa mtima.Kuphatikiza apo, milingo ya plasma idakweranso kumlingo wosiyanasiyana wa shuga, matenda a chiwindi, matenda a impso, chotupa cha glucagon ndi kupsinjika.Glucagon ili ndi ntchito zinayi zakuthupi zolimbikitsa glycogenolysis ya chiwindi, glycogenogenesis ya chiwindi, lipolysis ndi mapangidwe a ketone thupi.Ikhoza kulimbikitsa kuyamwa kwa ma amino acid m'maselo a chiwindi, kufulumizitsa ndondomeko ya deamination ya amino acid mu chiwindi, kuchepetsa kuchuluka kwa amino acid mu plasma, kuchepetsa kaphatikizidwe ka mapuloteni ndi kulimbikitsa chiwindi cha glycogenogenesis.Kuphatikiza apo, imatha kuyambitsanso mphamvu ya lipase ya maselo osungira lipid a chiwindi, kukulitsa kutulutsa kwamafuta acids aulere, kufulumizitsa njira ya lipoic acid oxidation yama cell a chiwindi, ndikuwonjezera kupanga kwa chiwindi glyccoconeogenesis ndi matupi a ketone.Nthawi yomweyo, glucagon imatha kuletsa kupsinjika ndi peristalsis ya m'mimba, matumbo ang'onoang'ono ndi m'matumbo, kuchepetsa kupsinjika kwa ndulu, kuletsa pancreatic exocrine, ndikuletsa kuyamwa kwamadzi ndi mchere ndimatumbo am'mimba.Mlingo waukulu wa glucagon ukhozanso kuonjezera kuchuluka kwa cAMP m'maselo a myocardial, kuonjezera kugunda kwa mtima ndi kukulitsa mgwirizano wa myocardial.