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Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide

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  • Dzina lodziwika:Exendin-4
  • Nambala ya CAS:141758-74-9
  • Molecular formula:Zithunzi za C184H282N50O60S
  • Kulemera kwa mamolekyu:4186.57188
  • Phukusi:Botolo, Chikwama, Katoni, Drum
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    Khalidwe:

    Dzina lodziwika Exenatide Dzina lachingerezi Exenatide acetate mchere
    Nambala ya CAS 141758-74-9
    Molecular formula Zithunzi za C184H282N50O60S
    Kulemera kwa maselo 4186.57000
    Misa yolondola 4184.03000
    PSA 1775.05000
    Zosungirako Osindikizidwa, sungani pa -20ºC
    Kukhazikika Palibe kuwola, palibe zowopsa zomwe zimadziwika ngati zitagwiritsidwa ntchito ndikusungidwa molingana ndi zomwe mukufuna

     

    Kagwiritsidwe:

    Exenatide ndiye mankhwala oyamba m'gulu latsopano la odwala matenda ashuga omwe amadziwika kuti incretin mimetics, ndipo amawonetsedwa ngati chithandizo chothandizira kukonza glycemic control mwa odwala omwe ali ndi matenda amtundu wa 2 omwe akumwa metformin, sulfonylurea, kapena onse awiri, koma sanatero. adapeza kuwongolera kokwanira kwa glycemic.Exenatide ndi analogue yogwira ntchito ya incretin yaumunthu Glucagon-Like Peptide-1 (GLP-1).GLP-1 imatulutsidwa mwachilengedwe m'maselo omwe ali mu thirakiti la GI poyankha kudya ndipo imagwira ntchito pa cholandirira chake pa ma b-cell kuti apangitse kutulutsa kwa insulin yolimbikitsa shuga.Exenatide ndi agonist wanthawi yayitali pa GLP-1 receptor.Ndi mtundu wopangidwa wa 39-amino acid peptide yomwe imapezeka m'malovu a buluzi wa Gila monster.amakhalanso owongolera kuchuluka kwa glucagon mu seramu panthawi ya hyperglycemic pambuyo pa chakudya, koma samasokoneza kutulutsidwa kwa glucagon poyankha hypoglycemia.Dosing regimen ya exenatide ndi 5 kapena 10 mg kawiri pa tsiku, kutumikiridwa ngati jekeseni wa subcutaneous mkati mwa ola limodzi musanadye m'mawa ndi madzulo.Pambuyo pa subcutaneous makonzedwe, kuchuluka kwapamwamba kwa exenatide mu plasma kumafika pambuyo pa maola 2.1, ndipo mbiri ya plasma ya pharmacokinetic ndiyolingana ndi mlingo.Zotsatira zoyipa zomwe zimanenedwa ndi exenatide ndi monga nseru, kusanza, kutsekula m'mimba, kumva kunjenjemera, chizungulire, kupweteka mutu, ndi dyspepsia.

    Exendin-4 imatha kuyambitsa cholandilira cha GLP-1, cholandiriracho chimatha kukulitsa milingo ya cAMP ya ma cell a pancreatic acinar mu intracellular, koma ilibe mphamvu pa VIP receptor.

    Exendin-4 yakhala ikugwiritsidwa ntchito ngati incretin mimetics pochiza ma cell a HepG2 kuti asaphatikizepo mphamvu ya zinthu zothandizira.Yagwiritsidwanso ntchito ngati r (GLP-1R) agonist kuchotsa kusokonezedwa ndi zinthu zothandizira.

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