Sarm S4 Andarine Yellow powder
Ndiuzeni
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Kugwiritsa ntchito
Andarine (S-4) ndi mankhwala opangidwa ndi arylpropionamide [S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide] poyamba yofotokozedwa ndi Yin et al.kukhala wosankha androgen receptor modulator (SARM).Andarine (S-4) inasonyezedwa ndi maphunziro a mu vitro ndi mu vivo kuti ndi anabolic agonist ogwira ntchito, opanda zotsatira zomwe nthawi zambiri zimagwirizanitsidwa ndi anabolic-androgenic steroids, zokhudzana makamaka ndi gawo logwirizana la 5α-reductase kuti apange DHT mu prostate.
Ntchito ya pharmacological ya andarine imasonyeza kuthekera kwakukulu kwa andarine pakupanga ma SARM omwe amapezeka kuchipatala, omwe amapereka ubwino wapadera wochiritsira kuposa anzawo a steroidal komanso mwayi wosangalatsa woyendetsa mosiyanasiyana zotsatira za androgen m'magulu osiyanasiyana omwe akutsata, motero kuchepetsa kusokoneza kwachibadwa. .Choncho, andarine akulonjeza mu mayesero apamwamba azachipatala omwe cholinga chake ndi kuchiza matenda okhudzana ndi ukalamba komanso kuthana ndi zizindikiro za matenda aakulu monga sarcopenia ndi cachexia ya khansa.
Andarine ndi wosankha nonsteroidal androgen receptor (AR) agonist ndi Ki wa 4 nM.Andarine amawonetsa ntchito za anabolic zamphamvu komanso zogwira mtima ndipo zimabweretsa kukondoweza kotengera kukula kwa prostate, ma seminal vesicles, motsatana.Andarine ali ndi mphamvu ya antiosteoporotic.
Andarine (omwe kale ankadziwika kuti GTx-007; S-4; GTx007; S4) ndi agonist yapakamwa komanso yosasankha yopanda steroidal androgen receptor (AR), makamaka yosankha androgen receptor modulator (SARM), yomwe imakhala yothandiza pakuwonongeka kwa minofu. ndi osteoporosis.Imayambitsa AR ndi Ki ya 4 nM ndipo imasankha minofu ya ziwalo za anabolic.Andarine akufufuzidwa pofuna kuchiza matenda monga kuwonongeka kwa minofu, osteoporosis ndi benign prostatic hypertrophy.Mu chitsanzo cha nyama cha benign prostatic hypertrophy, andarine inasonyezedwa kuti imachepetsa kulemera kwa prostate ndi mphamvu yofanana ndi finasteride, koma popanda kutulutsa kuchepa kwa minofu kapena zotsutsana ndi androgenic.
Zofotokozera
dzina wamba | Mtengo wa SARM S4 | Dzina lachingerezi | Andarine |
Nambala ya CAS | 401900-40-1 | kulemera kwa maselo | 441.358 |
kachulukidwe | 1.5±0.1g/cm3 | kuwira | 698.7±55.0 °C pa 760 mmHg |
mawonekedwe a molekyulu | C 19 H 18 F 3 N 3 O 6 | malo osungunuka | 70-74ºC |
PSA | 133.48000 | pophulikira | 376.4±31.5 °C |
LogP | 4.01 | kuthamanga kwa nthunzi | 0.0±2.3 mmHg pa 25°C |