China Hot Sale CAS 2894-68-0 Diclazepam

Kufotokozera

Diclazepam, yomwe imadziwikanso kuti 2-chlorodiazepam ndi chlorodiazepam, imayikidwa m'gulu la benzodiazepam, motero ndi analogue ya diazepam. Idapangidwa koyamba ndi Leo Sternbach ndi gulu lake ku Hoffman-La Roche mu 1960, koma sanatsatire ngati Mlingo wa Diclazepam, mphamvu kapena chitetezo mwa anthu sichinaphunzirepo mwalamulo.Mu nyama, komabe, amadziwika kuti ali ndi zotsatira zofanana kwambiri ndi flubromazepam ndi diazepam palokha.Zotsatira zake zimaphatikizapo kugwira ntchito ngati anticonvulsant ndi anxiolytic, sedative, hypnotic, amnesiac komanso ngati chigoba chotsitsimula minofu.Zitha kukhala ndi zotsatira zoyipa monga kugona, ndi kuwonongeka kwa chidziwitso monga kuwonongeka kwa kukumbukira kwakanthawi kochepa.
Diclazepam yayesedwa kuti ili ndi theka la moyo wa maola pafupifupi 42 mwa nyama zambiri.M'thupi, amakumana ndi N-demethylation, zomwe zimapangitsa kuti delorazepam ipangidwe.Delorazepam imatha kupezeka mumkodzo wamunthu pafupifupi masiku asanu ndi limodzi.Imasinthasinthanso kukhala lormetazepam (yodziwika kwa masiku 19) ndi lorazepam (yomwe imadziwika kwa masiku 11).Izi zikuwonetsa kuti ma enzymes a cytochrome P450 akugwiranso ntchito mu hydroxylation ya pawiri nthawi yomweyo N-demethylation.