Prostaglandins Chemical product 99%purity API Material Lumigan Bimatoprost CAS 155206-00-1 yochizira maso
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Kugwiritsa ntchito
Bimatoprost ndi mankhwala a prostaglandin omwe poyamba ankagwiritsidwa ntchito pochiza matenda a maso monga glaucoma.Dzina la mankhwala ndi Lumigan.Komabe, panthawi ya chithandizo, wodwalayo mosayembekezereka anapeza kuti m'mimba mwake, kutalika ndi kachulukidwe ka nsidze zake zawonjezeka kwambiri.Pambuyo pake, bimatoprost idagwiritsidwa ntchito m'mayesero azachipatala kukongola kwa nsidze.Zotsatira zake zazikulu pakukula ndi kukhuthala kwa eyelashes zidatsogolera mwachindunji kukhazikitsidwa kwa Lattise ndi kampani yopanga Lumegen, Allergan.Mankhwalawa adayambitsidwa mu Disembala 2008. Adavomerezedwa ndi US FDA, adakhala akatswiri opanga ma eyelashes akuda ndi makulidwe.
Mu July 2006, bimatoprost-timolol maleate compound madontho a maso opangidwa ndi United States Allergan Co., Ltd.Kuthamanga kwa intraocular kapena ocular hypertension kwa odwala omwe ali ndi glaucoma yotseguka omwe samayankha mokwanira ku chithandizo cha analogi.Madontho a diso a pawiri ali ndi 0.0Chemicalbook3% bimatoprost ndi 0.5% timolol maleate, kamodzi patsiku, amatha kupereka mankhwala othandiza kwambiri a intraocular pressure control effect, ndipo zotsatira zake zimakhala zabwino kuposa bimatoprost yokha.Matoprost kapena timolol maleate.Mayesero azachipatala atsimikizira kuti mankhwalawa ali ndi kulekerera kwakukulu, kuphatikizapo kuchepa kwa 40% kwa ocular hyperemia poyerekeza ndi bimatoprost yokha.
Pochiza glaucoma, itha kugwiritsidwanso ntchito mumadzimadzi akukula kwa nsidze, kuchuluka kwake ndi 0.03%
Zofotokozera
| Dzina lazogulitsa | Bimatoprost |
| CAS | 155206-00-1 |
| Kuchulukana | 1.1 ± 0.1 g/cm3 |
| Malo otentha | 629.8 ± 55.0 ° C AT 760 mmHg |
| Malo osungunuka | 66-68 ° C |
| Molecular | C25H37NO4 |
| Kulemera kwa maselo | 415.566 |
| pophulikira | 334.7 ± 31.5 ° C |
| Ubwino Wolondola | 415.272247 |
| PSA | 89.79000 |
| Lolemba | 1.98 |
| Maonekedwe | Crystal Olimba |
| Kuthamanga kwa nthunzi | 0.0 ± 1.9 mmHg PA 25 ° C |
| Refractive index | 1.591 |
| Zosungirako | 20 ° C |
Kafukufuku wina wa Bimatoprost CAS 155206-00-1:
Olaparib inali yothandiza polimbana ndi Brca1;p53 zotupa za m’mawere (50mg/kg jakisoni wa intraperitoneal patsiku), koma zinalibe mphamvu pa Ecad yosowa HR;p53 zotupa za m’mawere.Olaparib analibe poizoni woletsa mlingo mu mbewa zokhala ndi chotupa.Olaparib yakhala ikugwiritsidwa ntchito pochiza zotupa ndi kusintha kwa BRCA, monga khansa ya m'mawere, khansa ya m'mawere, ndi khansa ya prostate.Komanso, Olaparib analetsa ATM-akusowa chotupa maselo kusankha, kutanthauza kuti Olaparib angagwiritsidwe ntchito ngati wothandizira angathe kuchiza ATM-mutated lymphoid zotupa.
Olaparib ndi PARP inhibitor yomwe imachitanso motsutsana ndi kusintha kwa BRCA1 kapena BRCA2.Olaparib ilibe mphamvu pang'ono pa tanky (polymer) enzyme-1, ndipo mtengo wa IC50 ndi waukulu kuposa pamenepo.Olaparib pagulu la 30-100nM imagwira ntchito pama cell a SW620 kuti aletse PARP-1.BRCA1-deficient cell lines (MDA-MB-463[1] ndi HCC1937) imakhala yovuta kwambiri ku Olaparib poyerekeza ndi BRCA1- ndi BRCA2-cell lines yokwanira (Hs578T, MDA-MB-23, T47D) Olaparib imaletsa PARP ndi kukonza zoyambira , zomwe zimapangitsa chidwi champhamvu cha maselo a KB2P ku Olaparib.Chotsatira chake ndi kutembenuka kwa kuthyoka kwa chingwe chimodzi kukhala choduka chazingwe ziwiri panthawi ya DNA kubwerezabwereza, motero kuyambitsa njira yogwirizanitsa yodalira BRCA2.
Bimatoprost ndi chopangidwa ndi prostamide F2α chochokera, chomwe chitha kutsanzira momwe prostamine imapangidwira m'thupi, kuonjezera kuchuluka kwa nthabwala zamadzimadzi, kuchepetsa kukana kwamadzi oseketsa, ndikuwonjezera njira ya trabecular network ndi uveal sclera. kukhala mankhwala am'deralo odana ndi glaucoma omwe amathandizira kwambiri kuchepetsa kuthamanga kwa intraocular.Ndiwoyenera kuchiza open-angle glaucoma (POAG) kapena maso okwera omwe sagwira ntchito ndi mankhwala ena ochepetsa kuthamanga kwa intraocular.Odwala matenda oopsa (OHT).
Dziwani:
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