Mankhwala mankhwala Bromazolam CAS 71368-80-4
Zambiri Zoyambira
Mulingo wa molekyulu: C17H13BrN4
- Malo osungunuka: 272.0-275 ℃
- Malo otentha: 519.8±60.0 °C (Zonenedweratu)
- kachulukidwe: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40 (Zonenedweratu)
- Molecular formula: C17H13BrN4
- Kulemera kwa mamolekyu: 353.21600
- Kulemera kwake: 352.03200
- PSA: 43.07000
- Mtengo wa 3.12480
Kugwiritsa ntchito
Bromazolam imatchulidwa ngati buku la benzodiazepine lomwe linapangidwa koyamba mu 1976, koma silinagulitsidwe konse.Pambuyo pake adagulitsidwa ngati mankhwala opangira mankhwala, poyamba akudziwika motsimikizika ndi EMCDDA ku Sweden mu 2016. Ndi bromo m'malo mwa chloro analogue ya alprazolam, ndipo imakhala ndi zotsatira zofanana zochepetsera komanso nkhawa.Bromazolam ndi yofanana ndi yachikhalidwe cha benzodiazepines, kuphatikizapo alprazolam (kuchotsa chlorine ndi bromine) ndi bromazepam (kuwonjezera kwa mphete ya triazole).Alprazolam ndi bromazepam ndi zinthu za Pulogalamu IV ku United States;bromazolam sinakonzedwe momveka bwino.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine imagwiritsidwa ntchito pophunzira ntchito yolimbana ndi nkhawa, antidepressant ndi psychotropics yapakati yamanjenje.
Njira Yokonzekera
Anathandizidwa ndi pHLS9 (2 mg protein /mL), 25 μg/mL Alamethicin (UGT reaction mix B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, ndi 0.6 mM pa 37° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase ndi 0.1 mM acetyl-CoA.Kenako, 2.5 mM UDP-glucuronic acid (UGT reaction mix solution A), 40 μM PAPS, 1.2 mm SAM, 1 mM dithiothreitol, 10 mM glutathione, ndi 50 μM clobromazolam kapena Bromazolam anawonjezeredwa.
Zoyenera kuchita:50 μM Bromazolam kwa 360min mu 37°C
Mapulogalamu:Bromazolam metabolites analikudziwikamu pHLS9 makulitsidwe.