C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-α-aspartylglycylglycyl-

C-terminal peptide (CTX), yomwe imadziwikanso kuti carboxy-terminal collagen crosslinking, ndi C-terminal peptide ya ma fibrous collagen monga mtundu I ndi mtundu II.Amagwiritsidwa ntchito ngati biomarker mu seramu kuyeza kuchuluka kwa mafupa.Ikhoza kugwiritsidwa ntchito pothandizira madokotala kudziwa momwe wodwalayo akuyankhira chithandizo chamankhwala osachita opaleshoni, komanso kuyesa kuopsa kwa zovuta za wodwalayo panthawi ya machiritso pambuyo pochita opaleshoni.[1] Kuyesa kwa zolembera za CTX, zomwe zimatchedwa Serum CrossLaps, ndizokhazikika pakuwongolera mafupa kuposa mayeso ena aliwonse omwe alipo.

Kumayambiriro kwa zaka za m'ma 2000, chiyanjano chinadziwika pakati pa kugwiritsidwa ntchito kwa bisphosphonate ndi kuwonongeka kwa thupi ku mafupa.Kulepheretsa kwakukulu kwa osteoclast ntchito ndi bisphosphonate therapy kungayambitse kuponderezedwa kwa mafupa achibadwa, zomwe zimapangitsa kuti machiritso a mabala awonongeke pambuyo pa kuvulala (monga opaleshoni ya mano), komanso ngakhale kuwonetseredwa kwa mafupa osachiritsika.Chifukwa chakuti bisphosphonate imayikidwa m'mafupa omwe ali ndi chiwongoladzanja chachikulu, miyeso ya bisphosphonate mu nsagwada ikhoza kukwezedwa mosankha.

Pakubwera kwa mankhwala oika mano, odwala mano ochulukirachulukira akulandira chithandizo chokhudza kuchiritsa kwa mafupa m’kamwa, monga kuikidwa kwa opaleshoni ndi kulumikiza mafupa.Kuti awone chiopsezo cha osteonecrosis odwala omwe amatenga bisphosphonates, Rosen adayambitsa CTX biomarker mu 2000.