Vasoactive Intestinal Peptide CAS:40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE
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Ko nga peptides intestinal Vasoactive, e mohiotia ana ko nga peptides intestinal vasoactive, VIP ranei, he homoni peptide he vasoactive i roto i te kopu.Ko te VIP he peptide kei roto e 28 nga toenga waikawa amino no te glucagon/secretin superfamily, he hononga hoki no nga kaiwhakawhiwhi o te karaehe II G kua honoa te pūmua.Ka puta te VIP i roto i te maha o nga kopa vertebrate, tae atu ki te gut, pancreas, me te suprachiasmatic nucleus o te hypothalamus o te roro.Ko te VIP e whakaihiihi ana i te whakahekenga o te ngakau, ka whakaparahako, ka piki te pakaru o te glycogen, ka whakaheke i te toto toto totika me te whakangawari i nga uaua maeneene i roto i te pukoro, te puku me te gallbladder.I roto i te tangata, ka whakawaeheretia nga peptides intestinal vasoactive e nga ira VIP.
Ko te haurua o te ora (t ½) o te VIP i roto i te toto e rua meneti pea.
Ka whai paanga te VIP ki nga momo whakahaere:
I roto i te punaha nakunaku, ka puta te VIP ki te whakangā o te uaua maeneene (i raro iho o te esophageal sphincter, puku, gallbladder), ka whakaihiihi i te hunanga o te wai ki roto i te wai pancreatic me te ate, me te aukati i te hunanga me te whakauru o te waikawa pekiti mai i te kohanga whekau.Ko tana mahi i roto i te whekau ko te whakaihiihi nui i te hunanga o te wai me nga electrolytes, me te whakangawari i nga uaua maeneene o nga whekau, te whakawhanui i nga oko toto peripheral, te whakaihiihi i te hunanga o te bicarbonate na te pancreatic me te aukati i te whakangao o te waikawa gastric-stimulated gastric.Ka mahi tahi enei paanga ki te whakanui ake i te moti.Ka whakaihiihi hoki i te mahi huna o te pepsinogen e te pūtau matua.Ko te ahua o te VIP he neuropeptide nui i te wa o te mate whekau mumura na te mea ko te mast cell me te whakawhitiwhiti korero VIP kei te whakatikatika i te colitis penei i te mate a Crohn.
Kei roto ano i te ngakau me te whai paanga nui ki te punaha cardiovascular.Ka paheke te mate o te coronary me te pai o te inotropic me te chronotropic.Kei te haere tonu te rangahau ki te whakatau mena ka whai hua ki te rongoa i te ngoikore o te ngakau.Ka whakaihiihihia e te VIP te whakahinuhinu taratara i roto i nga wahine noa, ka ruarua te nui o te whakahinuhinu kua puta