Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507
Whakapā mai
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Whakamahinga
Ko te Tesamorelin (INN) (te ingoa hokohoko Egrifta SV) he ahua hangai o te homone tuku homoni tupu (GHRH) mo te maimoatanga o te lipodystrophy e pa ana ki te HIV me te mea i whakaaetia tuatahi i te 2010. He mea whakaputa me te whakawhanakehia e Theratechnologies, Inc. Canada.Ko te rongoa he peptide waihanga i tito mai i nga waikawa amino 44 katoa o te GHRH tangata me te taapiri o te roopu waikawa trans-3-hexenoic.
Te tikanga mahi
Ko Tesamorelin he pūhui N-terminus kua whakarerekehia i runga i te raupapa waikawa amino 44 o te GHRH tangata.He pai ake, he pai ake te ahua o te hanga waihanga i nga peptides taiao.He kaha ake ano te atete ki te wehenga na te dipeptide aminopeptidase i te GHRH tangata.Ka whakaihiihi i te whakahiato GH endogenous me te tuku me te whakanui ake i nga taumata o te tauwehe tipu rite-insulin (IGF-1).Ko te GH kua tukuna ka herea ki nga kaiwhakawhiwhi kei runga i nga momo okana tinana me te whakahaere i te hanganga tinana.Ko te nuinga o tenei ture na te whakakotahitanga o nga tikanga anabolic me te lipolysis.Heoi, ko te tikanga matua i kitea ai te tesamoline ki te whakaheke i te papatipu ngako tinana ko te whakahekenga o nga taumata triglyceride i muri i te lipolysis.