Teduglutide CAS:197922-42-2 Teduglutide(ALX-0600) Revestive
Whakapā mai
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Whakamahinga
Taumahi:
Ko Teduglutide, e mohiotia ana i te reo Ingarihi ko Teduglutide, he tairitenga o te glucagon-like peptide 2 (GLP-2), he homoni karekau e whakaheke ana i te putunga me te hunanga o te kopu me te whakahaere i te tipu, te whakatipu, me te whakatikatika o nga pūtau kei roto i te whaowhao.Ko te rongoa ka whakanui ake i te maha o enei pūtau, ka piki ake te whakauru ki roto i te kohanga iti me te whakaiti i te mate pukupuku.
Whakaritenga:
Ko te hanganga o te hanganga mowhiti e rima-mema e tino pa ana ki te waikawa amino tika o Asp, Asn ranei, a ko Gly te hanganga mowhiti tino ngawari ka honoa a Gly i mua i te Asp na te kore o te roopu tiaki me te iti o te aukati steric i te taha. mekameka.Na reira, kare e taea e te tikanga honohono raupapa ka hangaia nga waikawa amino N-terminal o Tedulu Chemicalbook peptide hei mowhiti e rima-mema i roto i te tukanga o te whakahiato, ka whakaiti i te ma.Na reira, hei whakaoti i te raruraru whakahekenga o te kongakonga Asp-Gly, ko tetahi kongakonga kua tiakina katoa me te hanganga e whakaatuhia ana i SEQIDNO:2 i whakahiato tuatahihia e te hononga o te wehenga.Ko te kongakonga tino tiakina ko te waikawa amino tuatahi ~ tuawha o te pito-N o te tidulutide, tae atu ki te hanganga Asp-Gly, katahi ka purea te kongakonga kua tiakina katoatia.Ko te kongakonga kua oti te whakamarumaru kua purea he wahanga totoka i honoa ki te kapia peptide kongakonga me te hanganga e whakaatuhia ana i SEQIDNO:12, a ka whakahaeretia te wehenga whakamutunga ki te tiki tidurotide.