SARM SR9011 Paura Raw Pharmaceutical Mo te Whakanuia te Whakangungu Whakangungu CAS 1379686-30-2

SARM SR9011 Paura Raw Pharmaceutical Mo te Whakanuia i te Whakangungu Whakangungu CAS 1379686-30-2 Whakaaturanga Whakaaturanga

whakaahuatanga poto:

Whakaahuatanga Hua Taipitopito

Ingoa Hua:SR9011
Hua e Pa ana:SR9009
CAS:1379686-29-9
Te ahua:Paura ma
Whakamahinga:Te hanga uaua
Tikanga Tukunga:EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Maama Nui:tāpiringa hanga tinana sarms, steroids sarms

Tukuna he imeera ki a matou

Taipitopito Hua

Tohu Hua

SR9011 Nga Taipitopito Tere

Cas No 1379686-29-9
Nga kupu taurite 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Tātai C23H31ClN4O3S
Te taumaha molucelar 479.03524

SR9011Whakaahuatanga

Ko te SR9011 he monomer methacrylate trifunctional e whakarato ana i te piri ki te whakarewa
taputapu.

Ko te SR9011 e taunakihia ana mo te whakamahi i roto i nga whakakikorua kua oti te rongoa o te peroxide, nga hiri, me nga plastisols-PVC.
Ko nga taumata whakamahinga o te 5% ki te 10% i te taumaha ka tūtohutia.

Ko te SR9011 he REV-ERB waihanga kaha me te motuhake.He pai hoki i roto i te vivo plasma/roro te whakaaturanga.
Ko nga kaiwhakawhiwhi karihi REV-ERB-α me REV-ERB-β ka whai waahi nui ki te whakahaere i te korero.
o nga pūmua karaka matua, te akiaki i nga riipene i roto i nga mahi me te pakia.Ko te whakahaeretanga o te SR9011 ka whakarereke
te whanonga circadian me te tauira circadian o te whakaaturanga ira karaka matua i roto i te hypothalami o nga kiore.
Ko te tauira korero porohita o te huinga o nga ira ira i roto i te ate, te uaua koiwi me te
I whakarereketia ano te kiko adipose, i hua ake ai te whakapaunga kaha.Te maimoatanga o te kai-whakaawe
kiore mōmoma ki SR9011 heke mōmona mā te whakaiti i te papatipu ngako me te tino pai ake dyslipidemia me hyperglycaemia.Ko enei hua e tohu ana ko nga riipene REV-ERB waihanga e arohia ana e te rongoa
ka whai hua pea te manawataki circadian ki te maimoatanga o nga mate moe me nga mate metabolic.

Me pehea te whakamahi i te SR9011?

In vitro: I whakamahia te SR9011 i te 5-10 μM te kukū i roto i te in vitro me te i roto i nga whakamatautau waea.
In vivo: I whakamahia te whakahaere IP o SR9011 i te 100 mg/kg kotahi, e rua ranei ia ra mo te 12-30
nga ra i roto i nga tauira kiore rereke.

Te whakahiato o SR9009 me SR9011

I whakahiatohia nga puhui ma te whakaheke whakaheke o te 5-nitro-2-thiophenecarboxaldehyde me te 4-chlorobenzylamine me te konutai triacetoxyborohydride i puta te amine tuarua.Ko te tuarua o te whakaurunga whakaheke me te 1-Boc-pyrrolidine-3-carboxaldehyde i puta mai te amine tuatoru.I tukinotia tenei puhui ki te waikawa trifluoroacetic hei tango i te roopu whakamarumaru-Boc, katahi ka tauhohe ki te ethyl chloroformate (SR9009) me te pentyl isocyanate (SR9011) hei hoatu i nga hua e hiahiatia ana.

SR9011COA

Tūemi	Whakatakotoranga	Hua
Te ahua	He paura kore kakara, tata ma, he ma ranei	haere
Tautuhi	Ko te wa pupuri o te tihi nui ko whakaū ki te RS	haere
Ngaronga i te whakamaroke	Kaua e neke ake i te 0.5%	0.33%
Whakamātautau(HPLC)	Kaua e iti iho i te 99.0%	99.59%
Te toenga mura	Kaua e neke ake i te 0.1%	haere
Te whakarewa taumaha	Kaua e neke ake i te 20 ppm	haere