Hua Hot Semaglutide CAS 910463-68-2 Hot

Whakataki ki te Somaglutide

Ko te Somaglutide he reanga hou o te GLP-1 (glucagon rite peptide-1) tairitenga i whakawhanakehia e Daminol me NovoNordisk.Ko te Somaglutide he momo inenga roa kua whakawhanakehia i runga i te hanganga taketake o Lilalutide, he pai ake te painga ki te maimoatanga o te mate huka momo 2.Kua oti i a Novo Nordisk nga rangahau 6 PChemicalbookbaseIIIa mo te werohanga Somaglutide, a ka tukuna he tono rehitatanga rongoa hou mo te werohanga ia wiki o Somaglutide ki te US Food and Drug Administration (FDA) i te Hakihea 5, 2016, me te tono whakamana hokohoko (MAA) ki Ko te rongoa Pakeha Awhakahaerenga (EMA).I tetahi atu taha, ko te whakaritenga a-waha mo ia ra mo te Somaglutide kei roto i te waahanga haumanu III.

Whakamahinga

Ko te Somaglutide he momo inenga roa kua whakawhanakehia i runga i te hanganga taketake o te liraglutide, he pai ake te painga ki te maimoatanga o te mate huka momo 2.

Rangahau

Ko te Semeglutide he tairitenga GLP-1 hou ka werohia i raro i te kiri kotahi i te wiki.Ko te Somaglutide he tairitenga GLP-1 roa i hangaia e Novo Nordisk mo te wa kotahi/w werohanga subcutaneous.Ka whakatauritea ki te liraglutide, he roa ake te mekameka ngako a Somaglutide me te piki haere o te hydrophobicity.Heoi, ka whakarereketia a Somaglutide me te PEG mekameka poto, a ka tino whakanuia tona hydrophilicity.I muri i te whakarereketanga o te PEG, kaore e taea e ia te whakakotahi noa me te albumin, ka hipokina te waahi hydrolysis o te DPP-4 enzyme, engari ka whakaitihia te whakakorenga renal, ka roa te haurua o te koiora me te whakatutuki i te painga o te huringa roa.Ko te Somaglutide a Novo Nordisk i whakairihia te DPP-4's Sigliptin, me te GLP-1's originator, long-acting exenatide (me hoahoa ki te whakataetae upoko ki te upoko me te pono o Lily. Kua roa te mahi whakaweti i te maakete).I roto i te whakamatautau, ko te horopeta nui o Somicalbook i heke te A1C1.6%, a ko te nui o te mate taimaha he 6 kg.I whakamahia te Somaglutide ki te tirotiro i te kaha me te haumaru o te 1.0mg Somaglutide i whakaritea ki te 2.0mg Exenatide kotahi i te wiki i roto i te 813 nga turoro me te mate huka momo 2.Ko te wa whakamatautau he 56 wiki, ka tango nga turoro i te 1-2 nga raau taero mate huka i te wa kotahi.I te Hakihea 2017, ka whakamanahia e te FDA te rongoa GLP-1 hypoglycemic ia wiki, Somaglutide i hangaia e NovoNordisk hei hokohoko i raro i te ingoa hokohoko Ozempic.E ai ki nga raraunga whakamatautau haumanu, ka taea e Ozempic te whakaheke i te taumata HbA1c ka whakaritea ki te placebo, Januvia o Merck, Bydureon o AstraZeneca me Lantus o Sanofi.I whakaatu ano te rongoa i te kaha ki te awhina i nga turoro ki te whakaheke taumaha.