Clobetasol propionateka taea te rongoa psoriasis.
kupu taurite:
17-propionate;cgp9555;Clobetasol 17- propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate; CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate
Whakamahinga:
Clobetasol PropionateKo te ahua tote propionate o te clobetasol, he corticosteroid waihanga kaupapa me nga taonga anti-inflammatory, anti-pruritic, me te vasoconstrictive.Ka whai hua te Clobetasol propionate ma te herea ki nga kaiwhakawhiwhi glucocorticoid cytoplasmic, katahi ka whakahohe i te whakaputanga ira i waenga i nga kaiwhakawhiwhi glucocorticoid.Ko te hua tenei i roto i te whakahiato o etahi pūmua anti-inflammatory, i te aukati i te whakahiato o etahi takawaenga mumura.Inaa, ko te clobetasol propionate te ahua ki te whakaawe i nga pūmua aukati phospholipase A2, na reira ka whakahaere i te tukunga o te waikawa arachidonic inflammatory precursor mai i te membrane phospholipids na te phospholipase A2.
Ko te Clobetasol propionate te hākawa 17-O-propionate o te clobetasol ka puta mai i te clobetasol me te waikawa propionic.He corticosteroid kaha, ka whakamahia ki te rongoa i nga momo mate kiri, tae atu ki te exzema me te psoriasis.
I patented Clobetasol propionate i te tau 1968 ka uru mai ki te rongoa i te tau 1978. Kei te waatea hei rongoa rongoa.Ka whakamahia te Clobetasol propionate mo te maimoatanga o nga momo mate kiri tae atu ki te eczema, te herpes labialis, te psoriasis, me te lichen sclerosus.Ka whakamahia ano hoki ki te rongoa i nga tini mate auto-immune, tae atu ki te alopecia areata, lichen planus (nga nodule kiri aukati aunoa), me te mycosis fungoides (T-cell skin lymphoma).Ka whakamahia hei maimoatanga tuatahi mo te GVHD whakapeka me te roa o te kiri.Ko te Clobetasol propionate (Cormax, Temovate, Embeline, Olux) tetahi o nga tino kaha o nga kaitohutohu e waatea ana i tenei wa, ka tohuhia mo te maimoatanga mo te wa poto o te mumura. nga mate hyperplastic ranei.He corticosteroid fluorinated waihanga.Ka nui ake te tere, te roa ranei o te whakautu i era atu corticosteroids.E taunaki ana kia 60 g/wiki te roa o te tono clobetasol kia kaua e neke atu i te 14 nga ra kaore he aukati, me te kore e whakamahia ki nga tamariki kei raro iho i te 12 tau.
Ko te otinga o te betamethasone 21-methanesulfonate (4 g) i roto i te dimethylformamide (25 ml) i tukinotia ki te lithium chloride (4 g) ka whakamahana te ranunga ki runga i te pati mamaoa mo te 30 meneti.Ko te waimehatanga ki te wai ka puta te hua masivesivá i rerystallized ki te utu i te puhui taitara, MP 226°C.
Ka huri te Clobetasol ki te propionate hei ahua whaihua ma te tauhohenga me te propionic anhydride.
Te wa tuku: Hanuere-05-2023