Sarm S4 Andarine Kowhai paura
Whakapā mai
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Whakamahinga
Ko Andarine (S-4) te pūhui arilpropionamide-i takea mai [S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl) -propionamide] tuatahi whakaahuatia e Yin et al.ki te waiho i te whiriwhiri androgen receptor modulator (SARM).Ko te Andarine (S-4) i whakaatuhia e nga rangahau in vitro me in vivo he agonist anabolic whai hua, kaore he paanga-taha e pa ana ki nga steroids anabolic-androgenic, e pa ana ki te hononga taapiri mo te 5α-reductase ki te whakaputa DHT i roto i te prostate.
Ko te mahi rongoora o te andarine e whakaatu ana i te kaha nui o te androgen i roto i te whakawhanaketanga o nga SARM e waatea ana i te haumanu, e tuku ana i nga painga rongoa ahurei mo o raatau taangata steroidal me te whai waahi whakaongaonga ki te rereke rereke i nga paanga androgen i roto i nga momo momo pukupuku, na reira ka whakaiti i te wawaotanga ki te noa. .No reira, kua oati a andarine i roto i nga whakamatautau haumanu matatau e whai ana ki te rongoa i nga mate e pa ana ki nga tau me te aukati i nga tohu o nga mate kino penei i te sarcopenia me te cachexia mate pukupuku.
Ko te Andarine he agonist kore-steroidal androgen receptor (AR) me te Ki o 4 nM.Ko te Andarine e whakaatu ana i te kaha me te kaha o te mahi anabolic me te hua ki te whakaihiihi i te horopeta-whakaaro o te tipu i roto i te prostate, vesicles seminal, ia.Kei a Andarine nga taonga antiosteoporotic.
Ko te Andarine (i mohiotia i mua ko GTx-007; S-4; GTx007; S4) he agonist-a-waha-a-waha me te maataki kore-steroidal androgen receptor (AR) agonist, ina koa he kaiwhakamaori whakangao i te androgen (SARM), he whai hua pea mo te mate o te uaua. me te osteoporosis.Ka whakahohehia te AR me te Ki o 4 nM me te kopa-whiriwhiri mo nga whekau anabolic.Kei te whakatewhatewhahia a Andarine mo te rongoa i nga ahuatanga penei i te moumou uaua, osteoporosis me te hypertrophy prostatic ngawari.I roto i tetahi tauira kararehe o te hypertrophy prostatic ngawari, i whakaatuhia te andarine ki te whakaheke i te taumaha prostate me te kaha rite ki te finasteride, engari kaore he whakaheke i te papatipu uaua me nga paanga taha anti-androgenic.
Whakatakotoranga
ingoa noa | SARM S4 | Ingoa Ingarihi | Andarine |
tau CAS | 401900-40-1 | taumaha ngota | 441.358 |
kiato | 1.5±0.1 g/cm3 | wāhi koropupu | 698.7±55.0 °C i te 760 mmHg |
tātai rāpoi ngota | C 19 H 18 F 3 N 3 O 6 | ira whakarewa | 70-74ºC |
PSA | 133.48000 | Ira hiko | 376.4±31.5 °C |
RangitakiP | 4.01 | pehanga kohu | 0.0±2.3 mmHg i te 25°C |