Melanocortin receptor Tetracosactide CAS 16960-16-0 Cosyntropin
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Characteristic:
| Common name | Tetracosactide | English name | Adrenocorticotropic Hormone Fragment 1-24 human |
|---|---|---|---|
| CAS number | 16960-16-0 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular formula | C136H210N40O31S |
| Molecular weight | 2933.437 |
| Accurate mass | 2931.580566 |
| PSA | 1184.02000 |
| LogP | -3.27 |
| Refractive index | 1.681 |
| Storage conditions | Sealed and protected from light |
Usage:
Tetracosactide is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Tetracosactide is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of Tetracosactide acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.
Adrenocorticotropic Hormone (1-24), human is used in the treatment of West syndrome. It activates G proteins. It stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells. It also enhances transcription of mitochondrial genes.
Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.
