Manufacture Supply 99% Purity White Powder Antitumor Polypeptide Pharma Grade Cancer Research MELITTIN CAS 20449-79-0

MELITTIN CAS 20449-79-0 Usage:

Melitin is the main active ingredient of bee venom. Beevenom is a kind of transparent venom with aromatic smell secreted by worker bee venom glands and accessory glands. When it is violated, it is discharged from the stinger. Among the many components of bee venom, melittin has the highest content, accounting for about 50% of the dry weight of bee venom, and it has high biological activity. Melittin is a linear peptide composed of 26 amino acids, with a relative molecular weight of 2849. Melittin has high biological activity. Modern pharmacological studies have shown that it has anti-inflammatory, analgesic, inhibiting platelet aggregation, anti-AIDS and many other effect. Melittin can produce a strong killing effect on a variety of tumor cells through different mechanisms, and is a very promising anti-tumor natural drug.

Melittin can inhibit the growth and reproduction of more than 20 kinds of Gram-positive and negative bacteria, and can also enhance the antibacterial efficacy of sulfonamides and penicillins. Melittin destroys the bacterial cell membrane by binding to the membrane to achieve the purpose of bacteriolysis. Both melittin and its six derivatives can change the function of T lymphocytes infected by HIV, inhibit HIV replication, and reduce the infectivity of the virus.

1. Direct killing effect In vitro experiments have confirmed that melittin has obvious killing effect on various tumor cell lines such as osteosarcoma, ovarian cancer, and glioma, and the killing effect is positively correlated with the dose. Melittin can kill tumor cells and prevent the growth of tumor cells, and has no obvious effect on the growth of normal cells. Melittin can insert into the cell membrane of K562 cells, form pores, promote Ca2+ inflow, increase the concentration of Ca2+ in cells, cause cell lysis, and directly kill K562 cells. It is generally believed that melittin dissolves the mitochondrial membrane of cells, inhibits the normal respiratory function of tumor cells, destroys their aerobic respiration ability, inhibits the growth of tumor tissue, and directly kills tumor cells.
2. Immunomodulatory effect Cellular immunity is an important defense factor for the body against tumors and viral infections. The state of the body's cellular immune function plays an important role in the occurrence and development of tumors. Enhancing cellular immune function can play a certain anti-tumor effect.
3. Induction of tumor cell apoptosis Apoptosis, also known as programmed cell death, is an active cell biological process controlled by a variety of genes. Therefore, apoptosis is an active process, which involves the activation, expression and regulation of a series of genes. Modern studies have shown that many chemotherapeutic drugs can achieve therapeutic purposes by inducing apoptosis in cancer cells. Whether to induce apoptosis has become one of the criteria for screening anticancer drugs.

Melittin can inhibit the activity of sPLA2 from various sources, and the inhibition rate of sPLA2 activity in the synovial fluid of RA patients can reach 96%. Therefore, the application of melittin can alleviate the development of RA.

Sub-dose melittin can significantly reduce the lysis rate of complement to cells. This protective mechanism may be related to melittin promoting Ca2+ influx, stimulating intracellular signal transduction system and protective protein synthesis. It is suggested that the application of appropriate amount of melittin has certain clinical value in the treatment of RA by Chemicalbook. In recent years, studies have shown that different concentrations of melittin can affect cell functions through different channels and exert a variety of biological effects. Appropriate application of melittin will provide new treatments for some diseases.