Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Medicinae usus
Toluene thiazide communiter pro leniendo, musculus relaxans et analgesicus.Tetanus saepius tractare.Xylazine medicamentis simillima est ut phenothiazine, antidepressants tricyclicis et clonidine.Sicut Papaver, saepe in compositione cum ketamine ponitur.Xylazine videtur minuere corporis sensus ad insulinum et glucosium susceptionem.Yohimbine alpha2 receptor adrenergicus est adversarius qui glucosos gradus ad gradus sanos reducere adhibitus est.Yohimbine adversae effectus laterales toluene thiazide in occasu clinico si intravenously administratum paulo post toluene thiazide administratur

pharmacodynamics

Xylazine est potens alpha 2 renergic agonist.Toluene thiazide et alii alpha2 receptoris agonistae adrenergici in toto corpore intra 30-40 minuta dato distribuuntur.Ob summam lipophilicitatem, toluene thiazide directe excitat receptores centrales α2 ac receptores peripherici in variis fibris.Sicut agonista, toluene thiazide consequitur in reducta neurotransmissione norepinephrine et dopamine in systematis nervosi centralis.Hoc facit per imitationem ligaminis norepinephrine ad autoreceptores in superficie presynaptica, quae evenit in feedback inhibitionis norepinephrine.

Xylazine etiam fungitur inhibitoris onerariae inhibendo functionem onerariam norepinephrinam a certatim inhibendo substratae onerariae.Thus, toluene thiazide signanter aucta K m et non ponitur V max.Hoc fieri potest per commercium directum cum regionibus quae cum locis ligaturae antidepressantibus includunt.Exempli gratia, toluene thiazide et clonidine impedimentum MIBG (analogo norepinephrine) per cellas neuroblastomas inhibent.Xylazine varias affinitates habet pro cholinergicis, serotonergicis, dopaminergicis, alpha1, adrenergicis, h 2-histaminibus et receptoribus opioideis.Eius structura chemica valde similis est cum phenothiazinis, antidepressantibus tricyclicis et clonidine.