Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Iji ọgwụ eme ihe
A na-ejikarị Toluene thiazide eme ihe dị ka ihe na-eme ka ahụ sie ike, na-enye ahụ ike na analgesic.A na-ejikarị ya agwọ tetanus.Xylazine yiri ọgwụ ndị dị ka phenothiazine, tricyclic antidepressants na clonidine.Dị ka ihe anestetiiki, a na-ejikarị ya na ketamine eme ihe.Xylazine dị ka ọ na-ebelata mmetụta anụ ahụ na insulin na nnabata glucose.Yohimbine bụ alfa2 adrenergic antagonist receptor antagonist nke ejirila belata ọkwa glucose na ọkwa ahụike.Yohimbine na-atụgharị mmetụta dị n'akụkụ nke toluene thiazide n'ụlọ ọgwụ ma ọ bụrụ na a na-enye ya n'ime intravenously obere oge ka enyechara toluene thiazide.

pharmacodynamics

Xylazine bụ agonist alfa 2 adrenergic nwere ike.Toluene thiazide na ndị ọzọ alpha2 adrenergic agonists na-ekesa n'ime ahụ n'ime nkeji 30-40 mgbe enyere ya.N'ihi lipophilicity ya dị elu, toluene thiazide na-akpali ndị na-anabata α2 etiti yana ndị na-anabata αadrenergic dị n'akụkụ anụ ahụ dị iche iche.Dị ka agonist, toluene thiazide na-ebute mbelata neurotransmission nke norepinephrine na dopamine n'ime sistemu ụjọ nke etiti.Ọ na-eme ya site n'iṅomi njikọ nke norepinephrine na autoreceptors n'elu presynaptic, nke na-ebute nzaghachi nzaghachi nke norepinephrine.

Xylazine na-arụkwa ọrụ dị ka onye na-egbochi njem site na igbochi ọrụ njem norepinephrine site na ịsọ mpi igbochi mbufe mkpụrụ.Ya mere, toluene thiazide mụbara Km nke ukwuu ma ọ naghị emetụta V max.Nke a nwere ike ime site na mmekọrịta ya na mpaghara ndị na-ejikọta na saịtị antidepressant.Dịka ọmụmaatụ, toluene thiazide na clonidine na-egbochi nnabata nke MIBG (analog norepinephrine) site na mkpụrụ ndụ neuroblastoma.Xylazine nwere njikọ dị iche iche maka cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, na ndị na-anabata opioid.Ọdịdị kemịkal ya dị nnọọ ka nke phenothiazines, tricyclic antidepressants na clonidine.