Tesamorelin CAS: 804475-66-9 Unii-mqg94m5eeo Th 9507
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Tesamorelin (INN) (aha ahia Egrifta SV) bụ ụdị sịntetịt nke hormone na-ewepụta homonụ na-eto eto (GHRH) maka ọgwụgwọ nke lipodystrophy metụtara HIV ma bụrụ nke a kwadoro na 2010. Emepụtara ya ma mepụta ya bụ Theratechnologies, Inc. Canada.Ọgwụ a bụ peptide sịntetik nke mejupụtara amino acid 44 niile nke GHRH mmadụ yana mgbakwunye nke otu trans-3-hexenoic acid.
Usoro nke ime ihe
Tesamorelin bụ ngwakọta N-terminus gbanwetụrụ dabere na usoro amino acid 44 nke GHRH mmadụ.Ụdị sịntetik a gbanwere dị irè ma kwụsie ike karịa peptides eke.Ọ na-eguzogidekwa mgbawa site na dipeptide aminopeptidase karịa GHRH mmadụ.Ọ na-akpali njikọ GH endogenous na ntọhapụ ma na-abawanye ọkwa nke insulin-dị ka ihe na-eto eto (IGF-1).GH ewepụtara wee jikọta ndị na-anabata ya na akụkụ ahụ dị iche iche ma na-ahazi nhazi ahụ.Iwu a bụ n'ihi nchikota anabolic na usoro lipolysis.Otú ọ dị, isi usoro a chọtara tesamoline iji belata oke abụba anụ ahụ bụ mbelata ọkwa triglyceride mgbe lipolysis gasịrị.