SARM SR9011 ntụ ntụ ntụ ọgwụ maka ịkwalite ntachi obi mmega ahụ CAS 1379686-30-2

SARM SR9011 Pharmaceutical Raw ntụ ntụ maka ịkwalite ntachi obi mmega ahụ CAS 1379686-30-2 Foto egosipụtara

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Nkọwa ngwaahịa zuru ezu

Aha ngwaahịa:SR9011
Ngwaahịa ndị emetụtara:SR9009
CAS:1379686-29-9
Ọdịdị:Ọcha ntụ ntụ
Ojiji:Ụlọ Akwara
Ụzọ mbupu:EMS, HKEMS, FEDEX, DHL, UPS, Aramex, wdg
Ìhè dị elu:ihe mgbakwunye anụ ahụ sarms, sarms steroid

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Nkọwa ngwaahịa

Mkpado ngwaahịa

SR9011 nkọwa ngwa ngwa

Nọmba Cas 1379686-29-9
Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl) -N-pentylpyrrolidine-
1-carboxamide
Usoro C23H31ClN4O3S
Ibu Molucelar 479.03524

SR9011Nkọwa

SR9011 bụ trifunctional methacrylate monomer nke na-enye adhesion pụrụ iche na metal
ihe eji eme ihe.

SR9011 ka akwadoro maka iji na peroxide gwọọ mkpuchi, sealants, na plastisols dabeere na PVC.
A na-akwado ọkwa ojiji nke 5% ruo 10% site na ịdị arọ.

SR9011 bụ ihe siri ike yana kpọmkwem REV-ERB.Ọ dịkwa mma na vivo plasma/mkpughe ụbụrụ.
Ndị na-anabata nuklia REV-ERB-a na REV-ERB-β na-arụ ọrụ dị mkpa n'ịhazi okwu ahụ.
protein na-arụ ọrụ nke ọma, na-arụ ọrụ na metabolism.Nchịkwa nke SR9011 gbanwere
omume circadian na usoro circadian nke isi okwu mkpụrụ ndụ elekere na hypothalami nke oke.
Usoro okwu circadian nke ọtụtụ mkpụrụ ndụ ihe nketa metabolic na imeju, akwara skeletal na
Agbanwekwara anụ ahụ adipose, na-ebute mmụba ume ike.Ọgwụgwọ nke nri kpatara
ụmụ oke buru ibu nwere SR9011 belatara oke ibu site na ibelata oke abụba yana mmụba nke dyslipidemia na hyperglycaemia.Nsonaazụ ndị a na-egosi na njikọ REV-ERB sịntetik nke na-elekwasị anya na ọgwụ
Rhythm nke circadian nwere ike ịba uru n'ịgwọ ọrịa ihi ụra yana ọrịa metabolic.

Otu esi eji SR9011?

In vitro: A na-eji SR9011 mee ihe na 5-10 μM itinye uche na vitro na nyocha cellular.
Na vivo: A na-eji nchịkwa IP nke SR9011 na 100 mg / kg otu ugboro ma ọ bụ ugboro abụọ kwa ụbọchị maka 12-30.
ụbọchị dị iche iche òké ụdị.

Njikọ nke SR9009 na SR9011

Ejikọtara ngwakọta site na mbelata amination nke 5-nitro-2-thiophenecarboxaldehyde na 4-chlorobenzylamine na sodium triacetoxyborohydride nyere amine nke abụọ.Amine mbelata nke abụọ nwere 1-Boc-pyrrolidine-3-carboxaldehyde wepụtara amine nke atọ.A na-emeso ogige a na trifluoroacetic acid iji wepụ Boc-echebe otu, wee meghachi omume na ethyl chloroformate (SR9009) ma ọ bụ pentyl isocyanate (SR9011) iji nye ngwaahịa ndị a chọrọ.

SR9011COA

Ihe	Nkọwapụta	Nsonaazụ
Ọdịdị	Ihe na-esighi isi, ọ fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ ntụ ntụ	ngafe
Identificaton	Oge njide nke isi kacha elu bụ gosi na RS	ngafe
Ọnwụ na ihicha	Ọ bụghị ihe karịrị 0.5%	0.33%
Nyocha (HPLC)	Ọ bụghị ihe na-erughị 99.0%	99.59%
Ihe fọdụrụ mgbanye	Ọ bụghị ihe karịrị 0.1%	ngafe
Igwe dị arọ	Ọ bụghị ihe karịrị 20 ppm	ngafe