Isiokwu nke mgbochi ịka nká aghọwo ihe na-ewu ewu n'afọ ndị na-adịbeghị anya, na ọmụmụ dị iche iche na-apụta na njedebe.
Mgbe ọ bụla, ụfọdụ ndị otu nyocha na-achọpụta ihe na-egbochi ịka nká nke nwere ike inyere anyị aka ibi ndụ otu narị afọ.
Anyị bụ́ ụmụ mmadụ nwere njedebe ndụ nke afọ 150, n'ihi na telomeres na-ebelata ntakịrị ihe kwa afọ abụọ ruo atọ, mkpụrụ ndụ nwere ike kewaa ihe dị ka ugboro 50, Hafrick nke telomere Theory kwuru.
E nwekwara ụfọdụ ndị ọkachamara nwere nchekwube na-ekwu: onye mbụ dịrị ndụ ruo 1000 afọ, a mụrụ, na ụwa anyị, nwere ike ịbụ gị oh.
Site na mmepe nke bayoloji biomolecular, otu ụbọchị anyị nwere ike ịchọpụta ihe anwansi nke ga-enyere anyị aka ibi ndụ ogologo.
Yabụ, na-ebi ndụ ahụike, rụsie ọrụ ike iji nweta ego, ma chere ka teknụzụ tozuo otu ụbọchị, ikekwe, ị nwere ike ibi ndụ ogologo ndụ.
Taa, a ga m ewebata gị ụfọdụ ihe mgbakwunye mgbochi ịka nká na-ekwe nkwa nke amaara, wee lelee ole na ole ị hụrụ.
1. Epitalon
Epitalon bụ peptide sịntetik na-egbochi ịka nká, nke sitere na amino acid yinye alanine-glutamine-asparagine-glycine, nke na-akwalite ọrụ telomerase n'ime ahụ iji nyere aka belata ọnụego ịka nká.
Telomeres dị ka okpu siri ike nke na-echebe DNA.Ọtụtụ chromosomes na ahụ nwere telomeres na nsọtụ abụọ;Isi ọrụ nke telomerase bụ inye aka ịnọgide na-adị ogologo nke telomeres n'ime ahụ.
A na-ejikọta ọrịa ụfọdụ na telomeres dị mkpụmkpụ, na-eduga n'ịka nká ngwa ngwa;Enwere ike iji Epitalon agwọ ọrịa ndị na-ebute ịka nká, dị ka ọrịa Bloom na ọrịa Werner.
Epitalon na-enyekwa aka belata ihe ize ndụ nke ọrịa ndị metụtara ụkọ telomerase, dị ka ọrịa shuga, n'ihi na ụkọ telomerase na-egbochi mmepụta insulin.
Peptide nwekwara ike inwe mmetụta dị mma na ahụike obi ma nwee ike inye aka gbochie ọrịa obi;Ndị ọkà mmụta sayensị na-enyocha ike ya n'ịgwọ etuto ahụ.
2: Curcumin
Turmeric bụ ngwa nri India nke ukwuu, curcumin bụkwa ihe kacha amụ na-arụ ọrụ na turmeric, nke nwere ihe mgbochi mkpali na antioxidant siri ike.
Nnyocha egosiwo na curcumin na-arụ ọrụ sirtuins (deacetylases) na AMPK (AMP-activated protein kinase), nke na-enyere aka ịka nká cell na ogologo ndụ.
Na mgbakwunye, egosila curcumin ịlụso mmebi cell ọgụ ma gbasaa ogologo ndụ nke ijiji mkpụrụ osisi, ikpuru, na oke;Ọ nwekwara ike igbu oge mmalite nke ọrịa ndị metụtara afọ ma belata mgbaàmà nke ọrịa ndị metụtara afọ
3: cannabinoid
Ogige ndị na-arụ ọrụ nke cannabis, nke a maara dị ka cannabinoids, bụ otu ogige terpenoid phenolic, nke a ma ama bụ tetrahydrocannabinol (THC) na cannabidiol (CBD).
CBD nwere ike ịlụso radicals n'efu na sel anụ ahụ ọgụ, na-eme dị ka onye na-ahụ maka antioxidant na mgbochi ịka nká.A na-agbakwunye ya na ngwaahịa nlekọta anụ ahụ ma na-ejikarị eme ihe iji belata mgbu na-adịghị ala ala, na-arụpụta nnukwu ihe
4: spermidine
Spermidine bụ ihe sitere n'okike nke spam, na ahụ anyị (ma nwoke ma nwanyị) na-emepụta ihe dị ka otu ụzọ n'ụzọ atọ n'ime ya, nke fọdụrụ na-esite na nri anyị.
Isi nri ya gụnyere: chiiz merela agadi, mushrooms, natto, ose green, germ wheat, kọlịflawa, broccoli, wdg.
Ndị Eshia nwere nnukwu acid arginous na nri ha, nke nwere ike jikọta ndụ ha ogologo.
Nnyocha na spermidine na-eto eto n'afọ ndị na-adịbeghị anya, a chọpụtakwara na ọ nwere mmetụta ndị a:
Gbatịa ogologo ndụ ahụike;
Meziwanye ọkwa ọgụgụ isi nke ndị agadi;
Mmetụta neuroprotective;
Mbelata ihe niile na-akpata ọnwụ;
Ọbara mgbali elu;
Inweta autophagy na igbu oge senescence;
Ọ na-eme ka ntutu na-eto ngwa ngwa na ntu na-esiwanye ike.
5: ahụ ketone
Otu n'ime isi ihe kpatara nri ketogenic ji ewu ewu bụ mbelata ibu na idoanya nke uche.
Mgbe ahụ malitere ọkụ abụba anụ ahụ, ọ na-emepụta ahụ ketone, nke na-enye ụbụrụ ume dị ọcha ma melite arụmọrụ ya.
Ketones nwere ihe mgbochi ịka nká, ọmụmụ achọpụtala na BHB (beta-hydroxybutyric acid) nwere ike ịkwalite nkewa cell, gbochie ịka nká cell, ma mee ka arịa ọbara na ụbụrụ na-eto eto.
Ahụ nwere ike imepụta ahụ keto site na ịzere carbohydrates, ma ọ bụ ọ nwere ike were mgbakwunye keto exogenous iji mee ka usoro ahụ dị ngwa wee belata mgbu nke mgbanwe, nke a maara dị ka “keto flu.”
Nri ketogenic, ma ọ bụ ị nweta ihe mgbakwunye keto exogenous, nwere ike belata ịka nká, melite arụmọrụ ọgụgụ isi, ma nyere aka gbochie ọrịa neurodegenerative dị ka Alzheimer.
6: Dasatinib
Ka anyị na-aka nká, ụfọdụ mkpụrụ ndụ anyị na-agbanahụ usoro ahụ ji alụso ọrịa ọgụ.Selụ “dị ndụ” ndị a anaghị eme ihe ha kwesịrị ime, mana ha ka na-ere ọkụ.
Mkpụrụ ndụ “nri niile na enweghị ọrụ” dị otú ahụ, nke a makwaara dị ka “sel sel zombie” ma ọ bụ mkpụrụ ndụ senescent, na-agbakọta ka oge na-aga, na-eme ka ahụ ghara ịrụ ọrụ nke ọma.
Ibu ọnụ, mmega ahụ na ụdị ndụ ahụike ndị ọzọ na-ebute autophagy, nke na-ehichapụ mkpụrụ ndụ zombie.
Dasatinib, ọgwụ chemotherapy nke a na-eji na-agwọ ọrịa leukemia, nwekwara ike wepụ mkpụrụ ndụ abụba ịka nká nke ọma ma belata nzuzo nke cytokines pro-inflammatory na anụ ahụ adipose.
Ọ bụ ọgwụ Senolytics nke mbụ ka achọpụtara, ọgwụ na-ahọrọ nke na-ehichapụ mkpụrụ ndụ senescent site na itinye aka na ụzọ mgbama mkpụrụ ndụ senescent, na-ewepụ nwa oge SCaps (ụzọ mgbochi apoptotic).
Ihe nwere ike ikpochapụ mkpụrụ ndụ senescent gụnyere PCC1 sitere na ụlọ akwụkwọ sayensị China, yana ihe ndị ọzọ dị ka quercetin.
Oge nzipu: Feb-24-2023