Enwere ike ịgwọ Clobetasol propionate na psoriasis? Ọrịa anụ ahụ niile?

Clobetasol propionateenwere ike ịgwọ psoriasis.

Ụdị okwu:

17-propionate; cgp9555; Clobetasol 17-propionate ngwọta,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propoonate; CLOBETASOL 17-PROPIONATE USP; -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;

Ojiji:

Clobetasol Propionatebụ ụdị nnu propionate nke clobetasol, corticosteroid synthetic dị n'elu nke nwere mgbochi mkpali, mgbochi pruritic, na vasoconstrictive Njirimara.Clobetasol propionate na-arụ ọrụ ya site na ijikọ na cytoplasmic glucocorticoid receptors ma mechaa mee ka mkpụrụ ndụ ihe nketa na-anabata glucocorticoid rụọ ọrụ.Nke a na-ebute njikọ nke ụfọdụ protein ndị na-egbochi mkpali, ebe ọ na-egbochi njikọ nke ụfọdụ mgbasa ozi mkpali.Kpọmkwem, clobetasol propionate na-egosi na ọ na-ebute protein phospholipase A2 inhibitory, si otú a na-achịkwa ntọhapụ nke inflammatory precursor arachidonic acid site na akpụkpọ ahụ phospholipids site na phospholipase A2.

Clobetasol propionate bụ 17-O-propionate ester nke clobetasol na ọ na-enweta site na clobetasol na propionic acid.Corticosteroid dị ike, a na-eji ya agwọ ọrịa akpụkpọ anụ dị iche iche, gụnyere exzema na psoriasis.
Clobetasol propionate bụ patented na 1968 wee bata n'ọrụ ahụike na 1978. Ọ dị ka ọgwụ ọnyà.A na-eji Clobetasol propionate maka ọgwụgwọ ọrịa akpụkpọ anụ dị iche iche gụnyere eczema, herpes labialis, psoriasis, na lichen sclerosus.A na-ejikwa ya na-agwọ ọtụtụ ọrịa na-alụso ọrịa ọgụ, gụnyere alopecia areata, lichen planus (nodules anụ ahụ na-egbochi onwe ya), na mycosis fungoides (T-cell skin lymphoma).A na-eji ya dị ka usoro ọgwụgwọ mbụ maka ma nnukwu na GVHD nke anụ ahụ. ma ọ bụ ọrịa hyperplastic.Ọ bụ corticosteroid sịntetik fluorinated.Ọ nwere ike ịkpata nzaghachi ngwa ngwa ma ọ bụ ogologo oge karịa corticosteroids ndị ọzọ dị n'elu.A na-atụ aro na clobetasol nwere oke ngwa nke 60 g / izu maka ihe na-erughị ụbọchị 14 na-enweghị oghere yana na e kwesịghị iji ya na ụmụaka na-erubeghị afọ 12.

A na-edozi ngwọta nke betamethasone 21-methanesulfonate (4 g) na dimethylformamide (25 ml) na lithium chloride (4 g) na ngwakọta kpụ ọkụ n'ọnụ na mmiri ịsa ahụ maka nkeji 30.Mgbasa mmiri na-enye ngwaahịa crude nke e recrystallized iji nweta aha aha, MP 226°C.
A na-atụgharịkarị Clobetasol na propionate dị ka ụdị bara uru site na mmeghachi omume na propionic anhydride.