Okwu mmalite
Minoxidil, nke a makwaara dị ka ogologo nrụgide idine, Minoxidil, usoro molecular na ịdị arọ molecular C9H15N5O = 209.25, bụ ọcha ma ọ bụ ọcha crystalline ntụ ntụ, soluble ntakịrị na mmiri ma ọ bụ chloroform, ntakịrị soluble na ethanol, ntakịrị soluble na acetone, soluble na acetic acid.Ọ nwere ike na-arụ ọrụ ozugbo na mgbidi arịa ọbara, gbasaa arterioles, belata nguzogide mpụta, belata ọbara mgbali elu, na ịbawanye ọnụọgụ obi na mmepụta obi.Agbanyeghị, mmetụta antihypertensive ya dị ịrịba ama ma na-adịgide adịgide karịa hydrazine.
Mmetụta ọgwụ
Minoxidil na-agbasa arterioles ozugbo, si otú a na-ebelata ọbara mgbali, mana amabeghị usoro ya.Ngwaahịa a anaghị agbasa venules.Mbelata nguzogide vaskụla dị n'akụkụ na-eduga n'ọ̀tụ̀tụ̀ obi reflex ngwa ngwa yana mmụba nke obi.Ọrụ Renin na-abawanye mgbe hypotension, na-ebute mmiri na njigide sodium.Ngwaahịa a anaghị emetụta vaskụla moto Chemicalbook reflex, yabụ hypotension orthostatic anaghị eme.Minoxidil bụ ọgwụ a na-ejikarị ma dị irè maka ọgwụgwọ ntutu isi, mana mmetụta ọgwụ ya na mkpụrụ ndụ e lekwasịrị anya abụghị nke doro anya.N'afọ ndị na-adịbeghị anya, ọmụmụ egosila na Minoxidil nwere ike ịkwalite uto ntutu site na ụzọ ndị a.
A na-eji ọgwụ ọnụ ọnụ eme ihe iji belata ọbara mgbali elu
Minoxidil bụ ụdị ọgwụ ọnụ na-eji maka ibelata ọbara mgbali na ụlọ ọgwụ, nke a makwaara dị ka Changbaridine, piperazine enediamine, hypotenidine na Minlohemoidine.Ọ bụ nke potassium ọwa oghere gị n'ụlọnga, nke nwere ike ozugbo izuike vaskụla ezigbo uru na nwere ike obere akwara dilatation mmetụta, mbenata mpụta eguzogide, vaskụla dilatation na ọbara mgbali, ma ọ dịghị mmetụta na olu arịa, n'ihi ya, ọ pụrụ ịkwalite venous nloghachi.N'otu oge ahụ, mmepụta obi na ọnụ ọgụgụ obi nwere ike ịba ụba n'ihi nhazi reflex na mmetụta dị mma ugboro ugboro, ma ọ dịghị akpata hypotension postural.Clinically eji na ọgwụgwọ nke refractory ọbara mgbali elu na gbasara akụrụ ọbara mgbali.Enwere ike iji ya maka ọbara mgbali elu siri ike na nzaghachi na-adịghị mma maka ọgwụ ndị ọzọ antihypertensive, ma ọ dị mkpa ijikọta ya na diuretics iji zere mmiri na njigide sodium.Mgbe ejikọtara ya na ọgwụ mgbochi β-egbochi, arụmọrụ ya nwere ike ịbawanye ma belata mmeghachi omume ọjọọ.Otu mmetụta nke iji Minoxidil na Chemicalbook eme ogologo oge bụ na ntutu anụ ahụ nwere ike ịbawanye ntakịrị site n'iji ọgwụ ahụ na-aga n'ihu, dị ka ntutu isi.Mana n'ozuzu n'ime oke anabatara.Ihe kachasị njọ nke nchịkwa ọnụ na-agụnye ịba ụba arọ na edema dị ala nke mmiri na njide sodium kpatara, palpitation na arrhythmia kpatara nhụsianya mmetụta ọmịiko ọmịiko, na hirsuism.Mmeghachi omume ọjọọ nke nkwadebe n'elu bụ mgbakasị anụ ahụ, erythema, itching na mmeghachi omume dermatitis ndị ọzọ.Ọ bụ ezie na ọnụ ọgụgụ nke absorption na nkwadebe n'elu dị ntakịrị, a pụghị ikpebi na ọ nwere ike imetụta ọnọdụ ndị ọrịa nwere akụkọ ihe mere eme nke ọrịa obi.Ndị ọrịa nwere ọrịa cerebrovascular, nkụchi obi na-abụghị nke ọbara mgbali elu, ọrịa obi obi, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction na ọrịa ndị ọzọ ga-eji nlezianya mee ihe, minoxidil allergies na pheochromocytoma ọrịa kwesịrị ka egbochiri ya.
Oge nzipu: Jan-06-2023