Mmepụta 99% Ọcha ọcha ntụ ntụ Antitumor Polypeptide Pharma Grade Cancer Research MELITTIN CAS 20449-79-0

MELITTIN CAS 20449-79-0 Ojiji:

Melitin bụ isi ihe na-arụ ọrụ nke venom aṅụ.Beevenom bụ ụdị venom na-apụta ìhè nke na-esi ísì ụtọ nke ndị ọrụ aṅụ venom glands na ngwa ngwa zoro ezo.Mgbe e mebiri ya, a na-ahapụ ya na stinger.N'ime ọtụtụ akụkụ nke venom aṅụ, melittin nwere ọdịnaya kachasị elu, na-aza ihe dị ka 50% nke akọrọ akọrọ nke venom aṅụ, ọ nwekwara nnukwu ọrụ ndu.Melittin bụ peptide linear nke nwere amino asịd 26, nwere ihe dị arọ molekụla nke 2849. Melittin nwere nnukwu ọrụ ndu.Ọmụmụ ọgwụ nke oge a egosila na ọ nwere mgbochi mkpali, analgesic, na-egbochi nchịkọta platelet, mgbochi AIDS na ọtụtụ mmetụta ndị ọzọ.Melittin nwere ike iwepụta mmetụta igbu egbu siri ike na mkpụrụ ndụ etuto dị iche iche site na usoro dị iche iche, ma bụrụkwa ọgwụ okike na-ekwe nkwa mgbochi tumor.

Melittin nwere ike igbochi uto na mmeputakwa nke ihe karịrị ụdị nje gram iri abụọ na-adịghị mma na nke na-adịghị mma, ma nwee ike ịkwalite nrụpụta antibacterial nke sulfonamides na penicillins.Melittin na-ebibi akpụkpọ ahụ nke nje bacteria site na ijikọta akpụkpọ ahụ iji nweta nzube nke bacteriolysis.Ma melittin na usoro ya isii nwere ike ịgbanwe ọrụ nke T lymphocytes bu nje HIV, gbochie nje HIV, ma belata nje virus ahụ.

1. Mmetụta igbu egbu ozugbo Nnwale vitro ekwenyela na melittin nwere mmetụta igbu ọchụ doro anya na ahịrị mkpụrụ ndụ etuto dị iche iche dị ka osteosarcoma, kansa ovarian, na glioma, yana mmetụta igbu egbu na-ejikọta ya na dose ahụ.Melittin nwere ike igbu mkpụrụ ndụ tumo ma gbochie uto mkpụrụ ndụ tumo, ọ nweghịkwa mmetụta doro anya na uto nke mkpụrụ ndụ nkịtị.Melittin nwere ike itinye n'ime akpụkpọ ahụ nke mkpụrụ ndụ K562, na-emepụta pores, na-akwalite ntinye nke Ca2 +, na-eme ka ntinye nke Ca2 + dị na sel, na-akpata cell lysis, ma gbuo mkpụrụ ndụ K562 ozugbo.A na-ekwenyekarị na melittin na-agbari akpụkpọ ahụ mitochondrial nke mkpụrụ ndụ, na-egbochi ọrụ iku ume nkịtị nke mkpụrụ ndụ tumo, na-emebi ike iku ume ha, na-egbochi uto nke anụ ahụ tumo, na-egbukwa mkpụrụ ndụ tumor ozugbo.
2. Immunomodulatory mmetụta Mgbochi cellular bụ ihe nchebe dị mkpa maka ahụ megide etuto na ọrịa nje.Ọnọdụ ọrụ mgbochi sel nke anụ ahụ na-ekere òkè dị mkpa na omume na mmepe nke etuto ahụ.Ịkwalite ọrụ mgbochi ọrịa cellular nwere ike ịme ụfọdụ mmetụta mgbochi tumor.
3. Mwelite nke cell tumor apoptosis Apoptosis, nke a makwaara dị ka ọnwụ cell emebere, bụ usoro ndụ ndụ cell na-arụ ọrụ nke mkpụrụ ndụ ihe nketa dị iche iche na-achịkwa.Ya mere, apoptosis bụ usoro na-arụ ọrụ, nke gụnyere ntinye, nkwupụta na nhazi usoro nke mkpụrụ ndụ ihe nketa.Ọmụmụ ihe nke oge a egosila na ọtụtụ ọgwụ chemotherapeutic nwere ike nweta ebumnuche ọgwụgwọ site n'ime ka apoptosis na mkpụrụ ndụ kansa.Ma ịkpalite apoptosis abụrụla otu n'ime njirisi maka nyocha ọgwụ mgbochi ọrịa kansa.

Melittin nwere ike igbochi ọrụ sPLA2 site na isi mmalite dị iche iche, yana nkwụsị nke ọrụ sPLA2 na mmiri synovial nke ndị ọrịa RA nwere ike iru 96%.Ya mere, ntinye nke melittin nwere ike ibelata mmepe nke RA.

Mbelata nke melittin nwere ike belata ọnụego lysis nke mmeju na sel.Usoro nchebe a nwere ike jikọta na melittin na-akwalite ntinye nke Ca2+, na-akpali akpali usoro ntụgharị mgbaàmà intracellular na njikọ protein nchebe.A na-atụ aro na itinye ego nke melittin kwesịrị ekwesị nwere uru ụlọ ọgwụ na ọgwụgwọ RA site na Chemicalbook.N'ime afọ ndị na-adịbeghị anya, ọmụmụ egosiwo na nchịkọta dị iche iche nke melittin nwere ike imetụta ọrụ cell site na ọwa dị iche iche ma nwee mmetụta dị iche iche nke ndu.Ngwa melittin kwesịrị ekwesị ga-enye ọgwụgwọ ọhụrụ maka ọrịa ụfọdụ.