Hygromycin A CAS: 6379-56-2 Homomycin

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Njirimara kemịkalụ:
Ọcha ntụ ntụ.Acid na-adịghị ike.Na-agbaze kpamkpam na mmiri na mmanya.Streptomyces hygroscopicus mepụtara.
Na-eji:
Hygromycin A, ọgwụ nje a na-eleghara anya, na-eji nlezianya gbuo nje bacteria na-akpata ọrịa Lyme.O nwere ike ịgwọ ọrịa Lyme n'ime ụmụ oke na-akpaghasịghị microbiome.
Ọgwụ (ọgwụ nje na-efe efe).
Nkọwa ChEBI: Ngwaahịa sitere n'okike achọtara n'ụdị Streptomyces.

SR 9009 bụ agonist sịntetik REV-ERB na-achịkwa omume circadian na metabolism;nwere ike iji na ọgwụgwọ nke ihi ụra na ọrịa metabolic.Ọ bụ ngwakọta ndu maka klaasị ọhụrụ nke ọgwụ ọrịa kansa jikọtara ya na elekere circadian nke anụ ahụ.

SR9009, makwaara dị ka Stenabolic, bụ ọgwụ nyocha dị ka agonist nke REV-ERB.
REV-ERB-a na REV-ERB-β, ndị na-anabata nuklia abụọ, nwere ọrụ dị oke egwu n'ịhazi okwu nke protein ndị na-ahụ maka elekere na-akwọ ụgbọ ala na ọrụ na metabolism.
In vitro: Ma SR9009 na analọg ya SR9011 nwere ike were-dabere na-abawanye ọrụ mmegide na-adabere na REV-ERB nke a na-enyocha na sel HEK293 na-ekwupụta ngalaba chimaeric Gal4 DNA: REV-ERB ligand binding domain α ma ọ bụ β na onye nta akụkọ luciferase Gal4 na-anabata. .Na mgbakwunye, SR9009 hụrụ na ọ nwere ike ịkwụsị okwu BMAL1 messenger RNA na sel HepG2 n'ụzọ dabere na REV-ERB-α/β.
Na vivo: A na-emeso ụmụ oke na otu dose nke SR9009, SR9011 ma ọ bụ ụgbọ ala na oge circadian 6 (CT6 (6h mgbe ọkụ ọkụ) gasịrị ụbọchị 12 na ọnọdụ D / D na-egosi ọnụ ọgụgụ kasị elu nke Rev-erb-α. Nsonaazụ gosiri na ụgbọ ala ahụ N'ụzọ dị iche, nchịkwa nke otu dose nke ma ọ bụ SR9009 ma ọ bụ SR9011 butere mfu nke ọrụ locomotor n'oge isiokwu gbara ọchịchịrị. Na mgbakwunye, ọrụ nkịtị weghachiri okirikiri circadian ọzọ, bụ nke na-agbanwe agbanwe na mkpochapụ ọgwụ n'ihe na-erughị awa 24.