Choroinic Gonadotrophin mmadụ HCG CAS: 9002-61-3

gonadotropin chorionic mmadụ (hCG) bụ homonụ glycoprotein nke sel endodermal placental zoro ezo.Isi ọrụ ya bụ ịkwalite corpus luteum, nke na-eme ka mmepụta estrogen na progesterone na-aga n'ihu, iji kwalite nhazi nke akpanwa decidual ma mee ka placenta na-eto ma tozuo okè.Ozugbo etinyere ẹmbrayo, mkpụrụ ndụ blastoderm na-amalite izobe hCG, yabụ enwere ike ikpebi afọ ime site na ọkwa hCG n'ime ọbara ma ọ bụ mmamịrị.

Ọ mejupụtara 244 amino acid residues, nwere molekụla arọ nke 36.7kDa na nha nke 7.5 × 3.5 × 3 nm.Ọ bụ heterodimer nwere otu α dị ka luteinizing hormone (LH), follicle-stimulating hormone (FSH) na thyrotropin (TSH), ma dị iche iche β subunit.Akụkụ α nwere ihe fọduru amino acid 92, na nke β nwere ihe fọdụrụ amino acid 145.

Njikọ hCG n'ime ụmụ nwanyị na-abawanye nke ukwuu mgbe a tụchara ime, na ọnụnọ hCG na plasma na mmamịrị bụ otu n'ime akara izizi nke afọ ime ma jiri ya mee nnwale afọ ime.

(1) Ọ nwere ọrụ nke FSH na LH iji nọgide na-adị ndụ ogologo oge nke ịhụ nsọ corpus luteum ma mee ka corpus luteum na-eme nsọ nwanyị ghọọ gestational corpus luteum;

(2) Kwalite aromatization nke androgens n'ime estrogen, na-akpali mmepụta nke progesterone;

(3) Na-egbochi mmetụta mkpali nke lectin osisi na lymphocytes, mmadụ chorionic gonadotropin nwere ike adsorbed n'elu nke mkpụrụ ndụ trophoblast, ka ịzenarị ọgụ nke embrayo trophoblast cell site nne lymphocytes;

(4) Ọrụ LH, tupu pituitary nwa ebu n'afọ na-ezobe LH, na-akpali testis nwa ebu n'afọ iji zoo testosterone iji kwalite ọdịiche nwoke na nwanyị;Ọ nwekwara ike ịkwalite mmepe nke gonadal, nwoke nwere ike kpalie ike nke mkpụrụ ndụ testis mesenchymal, na-abawanye mmepụta nke homonụ nwoke (testosterone).Ọ dị oke mkpa maka ọgwụgwọ ndị nwoke na-arịa ọrịa nkwonkwo pituitary, nke nwere ike ọ bụghị nanị ịkwalite mmepe gonad na mmepụta hormone nwoke, kamakwa ịkwalite mmepe nke àgwà mmekọahụ nke abụọ.

(5) Ọ nwere ike jikọta na onye na-anabata TSH nke mkpụrụ ndụ thyroid nke nne ma kpalie ọrụ thyroid.