GW-0742 SARM ntụ ntụ |GW610742 CAS 317318-84-6
Ojiji
Maka oke ibu, ọrịa shuga, dyslipidemia na ọrịa obi, ọgwụ nnwale pụtara iji chịkwaa lipids wee bulie ọkwa HDL, ma ọ bụ ezigbo cholesterol, n'ime ọbara.Ihe na-eme ka cell-permeable, thiazolyl compound na-arụ ọrụ dị ka onye nwere ike, mmekọrịta dị elu, PPARδ agonist.Na-egosipụta nhọrọ maka PPARδ tụnyere PPARA na PPARγ.Apụghị ọrụ ọ bụla megide ndị nnabata nuklia ma ọ bụ ndị na-abụghị nke nuklia.Kwuru na ọ na-abawanye mmụba cholesterol na okwu ABAC1 na macrophages, fibroblasts, na sel eriri afọ.
Cardarine na-eji ndị na-eme egwuregwu na-asọmpi n'ọtụtụ egwuregwu dị iche iche.Dịka ọmụmaatụ, ndị na-eme egwuregwu ntachi obi nwere ike ịbawanye ntachi obi mgbatị ahụ site na iji AICAR ọgwụ analog nke AMP, ma ọ bụ na-agba ọsọ cardarine solo.N'ihi ya, ha ga-enwe ike ka ukwuu iru RPM dị elu n'oge ha na-agba ọsọ na-enweghị ịkụda oke obi.Nke a ga-eme ka onye na-agba ọsọ / onye na-agba ígwè / onye na-egwu mmiri ghọgbuo oke obi ha wee gaa ogologo oge na-enweghị ikuku, na-eme ka nchịkọta a bụrụ ngwa agha dị egwu iji mee egwuregwu ntachi obi.N'ezie, site na ahụmahụ nkeonwe m nwere ike ịgwa na cardarine nwere ike ịkụ aka karịa 30-45 sekọnd oge 5K ma ọ bụrụ na ejiri ya na-eduga n'ọsọ.
Nkọwa
OKWU OKWU: Mfu abụba, mee ka ntachi obi dịkwuo mma, enweghị mmetụta ọ bụla, onye na-arụ ọrụ ahụ, ọgwụgwọ maka oke ibu gbakwunyere na-enyere aka idobe uka dị nro, na-abawanye uru ahụ.
A na-ejikọta Cardarine (GW-501516) na ụdị SARMS, Otú ọ dị na nhazi na nkọwa, ọ bụ PPAR modulator.Dị ka PPAR modulator, ọ na-eme ka protein kinase na-arụ ọrụ AMP ma na-akpali nnabata glucose na anụ ahụ skeletal.GW-501516 nwere ikike igbanwe nsogbu metabolism site na-akpali akpali oxidation fatty acid.A na-ewere ya dị ka ọgwụgwọ siri ike maka oke ibu na ọnọdụ ndị ọzọ metụtara ya.
GW501516 bụ aha ọgwụ Glaxo Wellcome (GW na-anọchi anya ụlọ ọrụ na ọnụọgụ bụ nke ngwaahịa).A makwaara ya dị ka GW-501,516, GW1516, GSK-516).Ọ bụ onye na-anabata PPARδ agonist nke ewereghị ya karịa ule ụlọ ọgwụ.Dị ka nke a, amachibidoro ya na egwuregwu.Ọ dabara n'ọtụtụ ebe na ndepụta ahụ, gụnyere kpọmkwem dị ka "ndị na-eme ihe ike na-eme ihe na-eme ihe na-eme ihe na-eme ihe (PPARδ) (dịka GW501516)".Mana ọ ga-abịakwa n'okpuru nwude ọhụrụ WADA ngalaba “ihe anaghị akwadoro” nke chọrọ ịkwụsị ọgwụ ọ bụla na-enyeghị ikike nke ndị egwuregwu na-eji.
GW501516 (nke a makwaara dị ka GW-501,516, GW1516, GSK-516) bụ PPAR & agonist nnabata nke e mepụtara na mmekorita n'etiti Ligand Pharmaceuticals na GlaxoSmithKline na 1990s, abanyela n'ime mmepe ụlọ ọgwụ dị ka onye nyocha ọgwụ maka ọrịa metabolic na ọrịa obi. , ma gbahapụrụ ya na 2007 n'ihi na nyocha anụmanụ gosiri na ọgwụ ahụ na-eme ka ọrịa cancer na-etolite ngwa ngwa n'ọtụtụ akụkụ ahụ.
Na 2007 nnyocha e bipụtara na-egosi na nnukwu doses nke GW501516 nyere ụmụ oke mere n'ụzọ dị ịrịba ama mma ha arụ ọrụ;A tụlere ọrụ ahụ n'ọtụtụ ebe na mgbasa ozi na-ewu ewu, wee butere ahịa ojii maka onye na-achọ ọgwụ na mmegide ya site n'aka ndị na-eme egwuregwu dị ka onye na-ahụ maka ọgwụ doping.
Ngwa
Ndị na-eme egwuregwu nwere ike iji GW501516 dị ka ọgwụ na-eme ka arụmọrụ ergogenic na-achịkwaghị ugbu a site na ụkpụrụ ma ọ bụ chọpụta site na nyocha ọkọlọtọ.Otu n'ime ndị nchọpụta bụ isi sitere na ọmụmụ banyere ntachi obi na-emewanyewanye nke mere na-emepụta ule mmamịrị iji chọpụta ọgwụ ahụ, ma mee ka ọ dị na Kọmitii Olympic nke Mba Nile.
GW na-akpali nnabata glucose na anụ ahụ skeletal.Ọ na-ere abụba ọkụ site na-akpali akpali oxidation fatty acid.A na-atụ aro ya dị ka ọgwụgwọ nwere ike ịgwọ oke ibu n'ihi ike ọ nwere ịgbaze abụba ngwa ngwa.Ọzọkwa, a na-ekwu na Cardarine na-abawanye HDL site na nkezi nke 79% (ezigbo cholesterol) ma belata LDL (cholesterol ọjọọ) na ule nke II ugbu a.GW 501516 bụ PPARδ agonist.Ndị a na-enyere aka ịbawanye ọkwa HDL gị site na nkwupụta nkwalite nke onye na-ebu cholesterol ABCA1.
GW na-akpali nnabata glucose na anụ ahụ skeletal.Ọ na-ere abụba ọkụ site na-akpali akpali oxidation fatty acid.A na-atụ aro ya dị ka ọgwụgwọ nwere ike ịgwọ oke ibu n'ihi ike ọ nwere ịgbaze abụba ngwa ngwa.Ọzọkwa, a na-ekwu na Cardarine na-abawanye HDL site na nkezi nke 79% (ezigbo cholesterol) ma belata LDL (cholesterol ọjọọ) na ule nke II ugbu a.GW 501516 bụ PPARδ agonist.Ndị a na-enyere aka ịbawanye ọkwa HDL gị site na nkwupụta nkwalite nke onye na-ebu cholesterol ABCA1.
Nkwakọ ngwaahịa & nnyefe
