Glucagon CAS: 16941-32-5 Glucagon (1-29) Human HCl GLUCAGON 1-37

Glucagon, nke a makwaara dị ka hyperglycemin na glucagon, bụ homonụ polypeptide kwụ ọtọ nke sel α nke agwaetiti pancreatic zoro ezo, nwere amino acid 29.Usoro ihe omimi ya na ịdị arọ molekụla ikwu ya bụ C153H225N43O49S=3482.8.A rụpụtala homonụ a na obodo m.Ntụ ntụ kristal dị ọcha na-ekpo ọkụ, enweghị isi, enweghị ụtọ.Na-adịghị ike na mmiri na ọtụtụ ihe mgbaze organic, soluble na itule acid na itughari lye.Ọtụtụ n'ime nkwadebe bụ nke hydrochloride ya, nke soluble na mmiri.Ugbu a amatala na glucagon ga-edobe iguzosi ike n'ezi ihe nke mkpụrụ ndụ ya ka o wee rụọ ọrụ physiological ya.Ọdịdị hyperglycemic nwere ike ịdị na-agbanwe agbanwe na mmadụ na anụ mamma (oke bekee, ehi, ezì, oke, wdg), mana dịtụ iche na nnụnụ.Ọ bụ hormone dị mkpa iji nọgide na-enwe shuga ọbara nkịtị.Isi ọrụ ya bụ ịgbalite phosphorylase na myocardium, kwalite decomposition glycogen ma nwee mmetụta catecholamin.Ya mere, ọ na-enwe mmetụta obi siri ike na obi, na-amụba ọnụ ọgụgụ obi, myocardial contractility na ọbara ọgbụgba.Cardioenhancement anaghị eso ya na mmụba nke obi obi, mana ọ na-abawanye ions calcium n'ime cardiomyocytes ma nwee ike ịgbalite adenosine cyclase na akpụkpọ anụ imeju na chemicalbook, na-akwalite njikọ nke adenosine phosphate cyclic na sel.A kọwo na Glucagon na-adị irè n'ọnọdụ ụfọdụ nke nkụda obi.Na mgbakwunye, ọkwa plasma mụbara ruo ogo dịgasị iche iche na ọrịa shuga, ọrịa imeju, ọrịa akụrụ, etuto glucagon na nrụgide.Glucagon nwere ọrụ physiological anọ nke na-akwalite imeju glycogenolysis, imeju glycogenogenesis, lipolysis na nhazi ahụ ketone.Ọ nwere ike ịkwalite nnabata nke amino acid na sel imeju, mee ka usoro deamination nke amino acid dị na imeju dịkwuo elu, belata ntinye nke amino acid na plasma, belata njikọ protein ma kwalite glycogenogenesis imeju.Na mgbakwunye, ọ nwekwara ike ịgbalite ikike lipase nke mkpụrụ ndụ nchekwa lipid imeju, na-abawanye ntọhapụ nke fatty acids n'efu, mee ka usoro oxidation lipoic acid dị ngwa ngwa nke mkpụrụ ndụ imeju, na ịbawanye mmepụta nke imeju glycoconeogenesis na ahụ ketone.N'otu oge ahụ, glucagon nwere ike igbochi esemokwu na peristalsis nke afọ, obere eriri afọ na eriri afọ, belata esemokwu nke gallbladder, na-egbochi exocrine pancreatic, ma gbochie mmịnye mmiri na nnu site na mucosa eriri afọ.Nnukwu doses nke glucagon nwekwara ike ịbawanye ntinye nke CAMP na sel myocardial, na-abawanye ọnụọgụ obi ma kwalite myocardial contractility.