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Exendin-4 CAS 141758-74-9 Exenatide Acetate Nnu Exenatide

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  • Aha nkịtị:Exendin-4
  • Nọmba CAS:141758-74-9
  • Usoro ihe omimi:C184H282N50O60S
  • Arọ molikula:4186.57188
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    Njirimara:

    Aha nkịtị Exenatide Aha bekee Exenatide acetate nnu
    Nọmba CAS 141758-74-9
    Usoro ihe omimi C184H282N50O60S
    Ibu molekụla 4186.57000
    Ezi uka 4184.03000
    PSA 1775.05000
    Ọnọdụ nchekwa Akara akara, chekwaa na -20ºC
    Nkwụsi ike Enweghị ire ere, enweghị mmeghachi omume dị ize ndụ amaara ma ọ bụrụ na ejiri ya ma chekwaa ya dịka nkọwapụta

     

    Ojiji:

    Exenatide bụ ọgwụ izizi na klaasị ọhụrụ nke mgbochi ọrịa shuga nke a maara dị ka incretin mimetics, yana egosipụtara dị ka ọgwụgwọ mgbakwunye iji meziwanye njikwa glycemic na ndị ọrịa nwere ụdị ọrịa shuga 2 nke na-ewere metformin, sulfonylurea, ma ọ bụ abụọ, mana enweghị. enweta njikwa glycemic zuru oke.Exenatide bụ analog na-arụ ọrụ nke mmadụ incretin Glucagon-dị ka Peptide-1 (GLP-1).A na-ahapụ GLP-1 site na mkpụrụ ndụ dị na traktị GI na nzaghachi nri nri ma na-eme ihe na-anabata ya na sel b iji mee ka insulin na-akpali akpali.Exenatide bụ agonist na-eme ogologo oge na onye na-anabata GLP-1.Ọ bụ ụdị sịntetik nke peptide 39-amino acid dị na nzuzo nzuzo nke Gila monster lizard. na-ebelata ọkwa glucagon kachasị elu n'oge hyperglycemic na-esote nri, mana ọ naghị egbochi mwepụta glucagon na nzaghachi nke hypoglycemia.Usoro onunu ogwu maka exenatide bụ 5 ma ọ bụ 10 mg ugboro abụọ kwa ụbọchị, a na-enye ya dị ka injection subcutaneous n'ime otu awa tupu nri ụtụtụ na mgbede.Mgbe nchịkwa subcutaneous gasịrị, a na-enweta mkpokọta plasma kacha elu nke exenatide n'ime awa 2.1, yana profaịlụ pharmacokinetic plasma bụ nha nha.Ihe omume ọjọọ a na-akọkarị na exenatide gụnyere ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, mmetụta jittery, dizziness, isi ọwụwa, na dyspepsia.

    Exendin-4 nwere ike ịgbalite onye na-anabata GLP-1, onye na-anabata ya nwere ike ịbawanye ọkwa CAMP nke mkpụrụ ndụ acinar pancreatic na intracellular, mana ọ nweghị mmetụta ọ bụla na nnabata VIP.

    A na-eji Exendin-4 mee ihe dị ka mimetics incretin maka ọgwụgwọ na sel HepG2 iji wepụ mmetụta nke ihe enyemaka.A na-ejikwa ya dị ka r (GLP-1R) agonist iji wepụ nnyonye anya na ihe enyemaka.

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