Ngwaahịa kemịkalụ Prostaglandins 99% ịdị ọcha API Ihe Lumigan Bimatoprost CAS 155206-00-1 maka ọgwụgwọ anya
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Bimatoprost bụ ọgwụ prostaglandin nke e bu ụzọ gwọọ ọrịa anya dị ka glaucoma.Aha ọgwụ a bụ Lumigan.Otú ọ dị, n'oge ọgwụgwọ, onye ọrịa ahụ na-atụghị anya ya na dayameta, ogologo na njupụta nke nku anya ya abawanyela nke ukwuu.Mgbe nke ahụ gasịrị, a na-eji bimatoprost mee ihe na ule ụlọ ọgwụ maka ịma mma nku anya.Mmetụta ya dị ukwuu na nku anya na-agbatị na ịgbatị ozugbo butere mwepụta nke Lattise nke ụlọ ọrụ mmepụta Lumegen, Allergan.Emere ọgwụ ahụ na Disemba 2008. N'ịbụ nke US FDA kwadoro, ọ ghọwo ngwaahịa ọkachamara maka ịgbaji na nku anya.
Na July 2006, bimatoprost-timolol maleate compound eye drops nke United States Allergan Co., Ltd. kwadoro site n'aka ndị na-ahụ maka ọgwụ EU maka ibelata nzaghachi nke ndị na-egbochi β-receptor blockers ma ọ bụ prostaglandins.Nrụgide intraocular ma ọ bụ ọbara mgbali elu anya na ndị ọrịa nwere glaucoma mepere emepe na-anabataghị nke ọma na ọgwụgwọ analog.Anya na-ekpuchi anya nwere 0.0Chemicalbook3% bimatoprost na 0.5% timolol maleate, otu ugboro n'ụbọchị, ọ nwere ike inye ọgwụgwọ nchịkwa intraocular dị irè nke ọma, na mmetụta dị mma karịa nke bimatoprost naanị.Matoprost ma ọ bụ timolol maleate.Nnwale ụlọ ọgwụ ekwenyela na ọgwụ ahụ nwere ikike nnabata dị mma, gụnyere mbelata 40% na ọnọdụ hyperemia anya ma e jiri ya tụnyere bimatoprost naanị.
Maka ọgwụgwọ glaucoma, a pụkwara iji ya mee ihe na mmiri mmiri na-eto nku anya, ntinye uche bụ 0.03%
Nkọwapụta
| Aha ngwaahịa | Bimatoprost |
| CAS | 155206-00-1 |
| Njupụta | 1.1 ± 0.1 g/cm3 |
| Ebe esi nri | 629.8 ± 55.0 ° C AT 760 mmHg |
| Ebe mgbaze | 66-68 Celsius C |
| Molecular | C25H37NO4 |
| Ibu arọ molekụla | 415.566 |
| ebe mgbari | 334.7 ± 31.5 Celsius C |
| Ogo ziri ezi | 415.272247 |
| PSA | 89.79000 |
| Ndekọ | 1.98 |
| Ọdịdị | Crystal siri ike |
| Nrụgide uzuoku | 0.0 ± 1.9 mmHg AT 25 Celsius |
| Ntụgharị ntụgharị | 1.591 |
| Ọnọdụ nchekwa | 20 Celsius C |
Ụfọdụ Bimatoprost CAS 155206-00-1 Nyocha:
Olaparib dị irè megide etuto ara Brca1;p53 (50mg/kg intraperitoneal injection kwa ụbọchị), mana enweghị mmetụta na HR-deficient Ecad; p53 etuto ara.Olaparib enweghị nsi na-egbochi dose na ụmụ oke na-ebu akpụ.A na-eji Olaparib gwọọ etuto ndị nwere mmụgharị BRCA, dị ka ọrịa cancer ovarian, ọrịa ara ara, na ọrịa prostate.Na mgbakwunye, Olaparib gbochiri mkpụrụ ndụ tumor enweghị ATM nke ọma, na-atụ aro na enwere ike iji Olaparib mee ihe dị ka onye nwere ike ịgwọ ọrịa etuto lymphoid nke ATM gbanwere.
Olaparib bụ ihe mgbochi PARP na-emekwa ihe megide mmụkọ BRCA1 ma ọ bụ BRCA2.Olaparib nwere obere mmetụta na tanky (polymer) enzyme-1, na uru IC50 dị ukwuu karịa nke ahụ.Olaparib na ntinye nke 30-100nM na-arụ ọrụ na sel SW620 iji mee ka PARP-1 rụọ ọrụ.Ahịrị cell BRCA1-deficient (MDA-MB-463[1] na HCC1937) na-enwe mmetụta uche na Olaparib ma e jiri ya tụnyere BRCA1- na ahịrị BRCA2 zuru ezu (Hs578T, MDA-MB-23,T47D) Olaparib na-egbochi PARP ma na-egbochi mmezi nkwụsịtụ isi. , na-ebute mmetụta siri ike nke mkpụrụ ndụ KB2P na Olaparib.Ihe si na ya pụta bụ ngbanwe nke nkwụsịtụ nke otu eriri gaa na nkwụsịtụ okpukpu abụọ n'oge mmegharị DNA, si otú a na-eme ka ụzọ nchikota dabere na BRCA2.
Bimatoprost bụ ihe na-emepụta prostamide F2a nke sịntetik, nke nwere ike ịhọrọ ịme ka mmetụta nke prostamine na-emepụta n'ime ahụ, mee ka ọnụ ọgụgụ nke mmepụta ihe ọchị na-eme ka ọ dịkwuo elu, belata nguzogide nke ihe ọchị na-apụta, ma na-abawanye ọwa netwọk trabecular na uveal sclera A na-atụle ya bụrụ ọgwụ mgbochi glaucoma mpaghara nke nwere mmetụta kachasị ike na mbenata nrụgide intraocular.Ọ dị mma maka ọgwụgwọ glaucoma mepere emepe (POAG) ma ọ bụ anya dị elu nke na-adịghị arụ ọrụ na ọgwụ ndị ọzọ na-ebelata nrụgide intraocular.Ndị na-arịa ọbara mgbali elu (OHT).
Ekwuru:
Ọ bụrụ na ị nwere mmasị, biko kpọtụrụ anyị n'efu, anyị ga-aza n'oge. Olileanya na anyị nwere nkwado.