Ngwaahịa kemịkalụ Bromazolam CAS 71368-80-4
Ozi bụ isi
Usoro ihe omimi: C17H13BrN4
- Ebe mgbaze: 272.0-275 ℃
- Ebe esi mmiri: 519.8± 60.0C (buru amụma)
- Njupụta: 1.54± 0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37± 0.40 (buru amụma)
- Ụdị ihe omimi: C17H13BrN4
- Arọ Molecular: 353.21600
- Ọnụ ọgụgụ nkịtị: 352.03200
- PSA: 43.07000
- Nọmba ederede: 3.12480
Ojiji
A na-ekewa Bromazolam dị ka akwụkwọ akụkọ benzodiazepine nke ewepụtara na 1976, mana ọ nweghị ahịa.E mesịa ere ya dị ka ọgwụ mmebe, nke mbụ EMCDDA na Sweden mara ya nke ọma na 2016. Ọ bụ bromo kama chloro analogue nke alprazolam, ma nwee mmetụta na-enye ọgwụ mgbochi na anxiolytic.Bromazolam dị ka usoro benzodiazepines ọdịnala, gụnyere alprazolam (iji bromine dochie chlorine) na bromazepam (mgbakwunye mgbanaka triazole).Alprazolam na bromazepam bụ ihe nhazi oge IV na United States;A naghị ahazi bromazolam n'ụzọ doro anya.
A na-eji 8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine iji mụọ ọrụ mgbochi nchegbu, antidepressant na psychotropics maka sistemụ ụjọ etiti.
Usoro nkwadebe
A na-emeso ha na pHLS9 (2 mg protein / ml), 25 μg/mL Alamethicin (UGT mmeghachi omume ngwakọta B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, na 0.6 mM na 37 ° C NADP +, 0.9 U/ml isocitrate dehydrogenase, 100 U/mL superoxide dismutase na 0.1 mM acetyl-CoA.Mgbe ahụ, 2.5 mM UDP-glucuronic acid (UGT mmeghachi omume ngwakọta ngwọta A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, na 50 μM clobromazolam ma ọ bụ Bromazolam.
Ọnọdụ mmeghachi omume:50 μM Bromazolam maka 360min na 37°C
Ngwa:Bromazolam bụ metabolitesmarana pHLS9 incubation.