CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) bụ ọgwụ ọhụrụ na-emetụta guanylate cyclase, nke nwere ike ịkpalite secretion nke eriri afọ nke mmiri eriri afọ ma mee ngwa ngwa nhịahụ.Otu polypeptide ọnụ nke mejupụtara amino acid 16 emebere iji ṅomie peptide eriri afọ mmadụ, uranyin.Pucanatide, nke Callisto Pharmaceuticals mepụtara na mbụ wee bufee ya na Synergy Pharmaceuticals, nke US Food and Drug Administration (FDA) kwadoro maka ọgwụgwọ nke CIC na ndị okenye na January 19, 2017. Pucanatide bụ analogues nke uroguanylin, cyclic polypeptide Chemicalbook nwere. 16 amino asịd.Ọ na-eme dị ka onye na-anabata guanylate cyclase agonist maka excretion sodium, na-achịkwa acid na ion base na tract gastrointestinal, na-eme ka mmiri na-ebuga n'ime eriri afọ, na ịba ụba peristalsis nke eriri afọ.Usoro ihe omume Pucanatide na metabolites ya na-arụ ọrụ na-ejikọta na enzymes GC-C ma na-arụ ọrụ na mpaghara n'elu lumen nke mkpụrụ ndụ epithelial eriri afọ.Ntinye nke GC-C enzyme na-abawanye ntinye nke intracellular na extracellular cyclic guanosine phosphate (cGMP), ebe mmụba nke intracellular cGMP ntinye uche na-akpali secretion nke chloride na bicarbonate n'ime eriri afọ lumen site na ion ọwa ịgbalite cystic fibrosis transmembrane regulatory. ihe (CFTR), nke na-abawanye ma na-eme ka mmiri nke eriri afọ na-agafe ngwa ngwa.