CAS: 152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

LVV-hemorphin-7 (LVV-h7) bụ peptide bioactive sitere na nbibi nke hemoglobin β-globin yinye.LVV-h7 bụ agonist kpọmkwem maka onye na-anabata angiotensin IV.Nnabata a bụ nke klaasị aminopeptidase (IRAP) na-achịkwa insulin ma nwee ọrụ oxytocin.N'ebe a, anyị bu n'obi nyochaa: i) ma LVV-h7 na-agbanwe omume nke anụ ahụ na-etinye uche na nzaghachi obi na nrụgide, na ii) usoro n'okpuru mmetụta LVV-h7 gụnyere ịgbalite onye na-anabata oxytocin (OT), nke nwere ike ịbụ nsonaazụ nke mbelata ọrụ proteolytic IRAP n'oge oge ọrụ.Oke Wistar okenye (270 -- 370 g) natara (ip) LVV-h7 (153 nmol/kg) ma ọ bụ onye na-ebu (0.1 ml).A na-eji ụkpụrụ dị iche iche eme ihe: i) Open Field (OP) ule maka egwuregwu / nchọpụta ihe omume;ii) Cross mazes dị elu (EPMs) maka omume ụjọ;iii) Nnwale igwu mmiri na-amanye (FST) maka omume ịda mbà n'obi na iv) ntụtụ ikuku maka nzaghachi obi obi na mkpughe nrụgide siri ike.A na-eji Diazepam (2 mg / kg) na imipramine (15 mg / kg) dị ka njikwa dị mma maka EPM na FST, n'otu n'otu.A na-eji OT receptor (OTr) antagonists atosiban (1 na 0.1 mg / kg) iji chọpụta ntinye aka nke ụzọ oxytocin.Anyị chọpụtara na LVV-h7: i) mụbara ọnụ ọgụgụ nke ntinye na oge ejiri na maze na ogwe aka mepere emepe, nke gosipụtara mgbochi nchegbu;ii) Mmetụta antidepressant na-akpali akpali na ule FS;iii) Mmụba nyocha na mmegharị;iv) agbanweghị nzaghachi obi na neuroendocrine maka oke nrụgide.Tụkwasị na nke ahụ, mmega ahụ na-abawanye na LVV-h7 na-ebute mmetụta antidepressant nke OTr antagonists weghachiri ya.Anyị kwubiri na LVV-h7 na-agbanwe omume nke onye na-anabata oxytocin gosipụtara n'akụkụ ya.