Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Kev siv tshuaj kho mob
Toluene thiazide feem ntau yog siv los ua cov tshuaj sedative, cov leeg nqaij so thiab ua kom mob plab.Nws feem ntau yog siv los kho tetanus.Xylazine zoo ib yam li cov tshuaj xws li phenothiazine, tricyclic antidepressants thiab clonidine.Raws li kev siv tshuaj loog, nws feem ntau siv ua ke nrog ketamine.Xylazine zoo li txo lub cev rhiab heev rau insulin thiab qabzib uptake.Yohimbine yog ib qho alpha2 adrenergic receptor antagonist uas tau siv los txo cov piam thaj mus rau qib noj qab haus huv.Yohimbine thim rov qab cov kev mob tshwm sim ntawm toluene thiazide nyob rau hauv qhov chaw kho mob yog tias siv tshuaj intravenously tsis ntev tom qab toluene thiazide raug tswj hwm.

pharmacodynamics

Xylazine yog ib qho muaj zog alpha 2 adrenergic agonist.Toluene thiazide thiab lwm yam alpha2 adrenergic receptor agonists raug faib thoob plaws hauv lub cev li ntawm 30-40 feeb thaum muab.Vim nws cov lipophilicity siab, toluene thiazide ncaj qha nkoos central α2 receptors thiab peripheral αadrenergic receptors nyob rau hauv ntau yam ntaub so ntswg.Raws li ib tug agonist, toluene thiazide ua rau txo cov neurotransmission ntawm norepinephrine thiab dopamine nyob rau hauv lub hauv paus paj hlwb.Nws ua li ntawd los ntawm kev ua raws li kev khi ntawm norepinephrine rau autoreceptors ntawm qhov chaw presynaptic, uas ua rau kev tawm tswv yim inhibition ntawm norepinephrine.

Xylazine kuj ua raws li kev thauj mus los inhibitor los ntawm inhibiting norepinephrine thauj muaj nuj nqi los ntawm kev sib tw inhibiting substrate thauj.Yog li, toluene thiazide ho nce K m thiab tsis cuam tshuam rau V max.Qhov no yuav tshwm sim los ntawm kev sib cuam tshuam ncaj qha nrog cov cheeb tsam uas sib tshooj nrog cov tshuaj tiv thaiv kab mob sib txuas.Piv txwv li, toluene thiazide thiab clonidine inhibit qhov nce ntawm MIBG (ib qho norepinephrine analogue) los ntawm cov hlwb neuroblastoma.Xylazine muaj qhov sib txawv rau cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, thiab opioid receptors.Nws cov qauv tshuaj zoo ib yam li phenothiazines, tricyclic antidepressants thiab clonidine.