Vasoactive plab hnyuv Peptide CAS: 40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE

Vasoactive plab hnyuv peptides, tseem hu ua vasoactive plab hnyuv peptides lossis VIP, yog cov tshuaj peptide uas muaj vasoactive hauv plab.VIP yog peptide muaj 28 amino acid residues uas belongs rau glucagon/secretin superfamily thiab yog ib tug ligand ntawm Class II G protein-coupled receptors.VIP yog tsim nyob rau hauv ntau vertebrate cov ntaub so ntswg, nrog rau lub plab, pancreas, thiab suprachiasmatic nucleus ntawm lub hlwb hypothalamus.VIP nkoos lub plawv contraction, ua rau vasodilation, ua rau kom glycogen puas, txo cov ntshav siab thiab so cov leeg du nyob rau hauv lub trachea, plab thiab gallbladder.Hauv tib neeg, vasoactive plab hnyuv peptides yog encoded los ntawm VIP noob.

Ib nrab-lub neej (t ½) ntawm VIP hauv cov ntshav yog li ob feeb.

VIP muaj feem cuam tshuam rau ntau lub koom haum:

Nyob rau hauv lub digestive system, VIP zoo li yuav ua rau kom cov leeg du (sphincter esophageal sphincter, plab, gallbladder), tsub kom tso dej tso rau hauv cov kua tsib thiab cov kua tsib, thiab inhibit secretion thiab nqus ntawm gastric acid los ntawm txoj hnyuv kab noj hniav.Nws lub luag haujlwm hauv plab yog txhawm rau ua kom muaj dej thiab electrolytes, nrog rau kev ua kom lub plab zom mov du, nthuav cov hlab ntsha peripheral, txhawb kev tso tawm ntawm bicarbonate los ntawm txiav txiav thiab inhibit gastrin-stimulated gastric acid secretion.Cov teebmeem no ua haujlwm ua ke kom muaj zog ntxiv.Nws kuj txhawb kev tso pa tawm ntawm pepsinogen los ntawm lub xov tooj tseem ceeb.VIP zoo li yog ib qho tseem ceeb neuropeptide thaum lub sij hawm inflammatory plob tsis so tswj kab mob vim mast cell thiab VIP kev sib txuas lus yog upregulated nyob rau hauv colitis xws li Crohn tus kab mob.

Nws kuj tseem muaj nyob rau hauv lub plawv thiab muaj kev cuam tshuam tseem ceeb ntawm cov hlab plawv.Nws ua rau coronary vasodilation thiab muaj qhov zoo inotropic thiab chronotropic teebmeem.Kev tshawb fawb tab tom txiav txim siab seb nws puas muaj txiaj ntsig zoo hauv kev kho mob plawv.VIP stimulates qhov chaw mos lubrication nyob rau hauv ib txwm cov poj niam, ob npaug rau tag nrho cov nyiaj ntawm lubrication ua